Projects per year
Personal profile
Chinese Name
Biography
Prof. Chong obtained his MPhil and PhD in Immunology from the Department of Paediatrics and Adolescent Medicine at The University of Hong Kong. He received his postdoctoral training in immunology from the National Eye Institute at National Institutes of Health (NIH) in Bethesda, MD, USA. After that, he was appointed as the Associate Professor at the Key State Laboratory of Ophthalmology, Sun Yat-sen University in Guangzhou, China. He joined the School of Chinese Medicine, Hong Kong Baptist University, as the Associate Professor in 2022.
Dr. Chong's research centers on the cellular and molecular mechanism involved in immunoregulation and autoimmunity, and discovering novel therapeutic drug for autoimmune diseases. His works on autoimmunity have been well recognized and published in prestigious journals, including Immunity, Journal of Experimental Medicine, Journal of Autoimmunity, Hepatology and Journal of Infection.
Research Interests
Prof. Chong’s interest is in cellular and molecular mechanisms involved in regulating immune responses in autoimmune diseases. To better dissect the basic mechanisms involved, we used various animal models, including experimental autoimmune encephalomyelitis (EAE) and experimental autoimmune uveitis (EAU) to understand the disease pathogenesis. The goal is to translate our observations from these studies for the development of novel approaches for immunotherapy.
Biography
莊教授於香港大學兒科學系取得免疫學哲學碩士及博士學位,其後於美國國立衛生研究院(NIH)轄下的國家眼科研究所(NEI)接受免疫學博士後培訓。完成培訓後,他獲聘為中國廣州中山大學眼科中心眼科學國家重點實驗室副教授,並於2022年加入香港浸會大學中醫藥學院擔任副教授。
莊教授的研究聚焦於免疫調節與自身免疫疾病的細胞及分子機制,並致力發掘治療自身免疫疾病的新型藥物。他在自身免疫領域的研究成果備受認可,並發表於多份知名期刊,包括《Immunity》、《Journal of Experimental Medicine》、《Journal of Autoimmunity》、《Hepatology》及《Journal of Infection》。
莊教授的研究興趣在於探索自身免疫疾病中調控免疫反應的細胞及分子機制。為深入剖析相關基礎機制,其團隊運用多種動物模型,如實驗性自身免疫性腦脊髓炎(EAE)及實驗性自身免疫性葡萄膜炎(EAU),以解析疾病發病機制。研究目標是將這些基礎研究的發現轉化為新型免疫治療策略的開發。
Expertise related to UN Sustainable Development Goals
In 2015, UN member states agreed to 17 global Sustainable Development Goals (SDGs) to end poverty, protect the planet and ensure prosperity for all. This person’s work contributes towards the following SDG(s):
Keywords
- QR180 Immunology
- QH426 Genetics
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Collaborations and top research areas from the last five years
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The Role of Interleukin 24 in Regulating Ocular Inflammation: a Novel Cytokine for the Treatment of Autoimmune Uveitis
CHONG, W. P. (PI)
6/06/25 → 30/11/26
Project: Research project
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The role of Interleukin 24 in regulating ocular inflammation: a novel cytokine for the treatment of autoimmune uveitis
CHONG, W. P. (PI), REN, K. (Collaborator), Caspi, R. R. (Collaborator), Calvin CP , P. (Collaborator) & Chu, W. K. (Collaborator)
1/12/24 → 30/11/26
Project: Research project
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Equipment Matching Fund - High-performance Slide Scanner
LIU, J. (PI), LI, F. (CoI), YU, Y. (CoI), XU, J. (CoI), FU, X. (CoI), WONG, H. L. X. (CoI), KWAN, H. Y. (CoI) & CHONG, W. P. (CoI)
26/03/24 → 25/03/26
Project: Research project
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细胞因子 IL-24 通过抑制自身反应性 T 细胞和视网膜色素上皮改善实验性自身免疫性葡萄膜炎
CHONG, W. P. (PI)
1/01/24 → 31/12/27
Project: Research project
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The role of Interleukin 24 in regulating ocular inflammation: a novel cytokine for the treatment of autoimmune uveitis
CHONG, W. P. (PI) & Caspi, R. (Collaborator)
1/09/23 → 30/06/24
Project: Research project
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Regulatory T cell intravitreal delivery using hyaluronan methylcellulose hydrogel improves therapeutic efficacy in experimental autoimmune uveitis
Zhang, T., Han, X., Zhong, Y., Kam, H. T., Qiao, D., Chen, Z., Chan, K. W. Y., Chong, W. P. & Chen, J., Aug 2023, In: Biomaterials Advances. 151, 213496.Research output: Contribution to journal › Journal article › peer-review
4 Citations (Scopus) -
Induction of antigen-specific Treg cells in treating autoimmune uveitis via bystander suppressive pathways without compromising anti-tumor immunity
Chen, Z., Zhang, T., Kam, H. T., Qiao, D., Jin, W., Zhong, Y., Zhou, M., Zhou, H., Chong, W. P., Chen, W. & Chen, J., Aug 2021, In: EBioMedicine. 70, 12 p., 103496.Research output: Contribution to journal › Journal article › peer-review
Open Access17 Citations (Scopus) -
The Cytokine IL-17A Limits Th17 Pathogenicity via a Negative Feedback Loop Driven by Autocrine Induction of IL-24
Chong, W. P., Mattapallil, M. J., Raychaudhuri, K., Bing, S. J., Wu, S., Zhong, Y., Wang, W. W., Chen, Z., Silver, P. B., Jittayasothorn, Y., Chan, C. C., Chen, J., Horai, R. & Caspi, R. R., 18 Aug 2020, In: Immunity. 53, 2, p. 384-397.e5 19 p.Research output: Contribution to journal › Journal article › peer-review
Open Access131 Citations (Scopus) -
Functional polymorphisms of the CCL2 and MBL genes cumulatively increase susceptibility to severe acute respiratory syndrome coronavirus infection
Tu, X., Chong, W. P., Zhai, Y., Zhang, H., Zhang, F., Wang, S., Liu, W., Wei, M., Siu, N. H. O., Yang, H., Yang, W., Cao, W., Lau, Y. L., He, F. & Zhou, G., Jul 2015, In: Journal of Infection. 71, 1, p. 101-109 9 p.Research output: Contribution to journal › Journal article › peer-review
Open Access77 Citations (Scopus) -
NK-DC crosstalk controls the autopathogenic Th17 response through an innate IFN-γ-IL-27 axis
Chong, W., van, P. N., Chen, J., Silver, P. B., Jittayasothorn, Y., Mattapallil, M. J., Germain, R. N. & Caspi, R. R., 7 Sept 2015, In: Journal of Experimental Medicine. 212, 10, p. 1739-1752Research output: Contribution to journal › Journal article › peer-review
66 Citations (Scopus)
Prizes
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The 2020 William E. Paul Best Paper in Cytokine Research Award
CHONG, W. P. (Recipient), 10 Jun 2021
Prize: Award
Activities
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Cell Reports (Journal)
CHONG, W. P. (Reviewer)
19 Feb 2025Activity: Publication peer-review/editorial work › Editor/reviewer for publications (incl. CDCF T61 Journal Editor)
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International Journal of Biological Macromolecules (Journal)
CHONG, W. P. (Reviewer)
15 Apr 2025Activity: Publication peer-review/editorial work › Editor/reviewer for publications (incl. CDCF T61 Journal Editor)
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Advanced Science (Journal)
CHONG, W. P. (Reviewer)
13 Jun 2025Activity: Publication peer-review/editorial work › Editor/reviewer for publications (incl. CDCF T61 Journal Editor)
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Discover Immunity (Journal)
CHONG, W. P. (Member of editorial board)
15 Jan 2024 → …Activity: Publication peer-review/editorial work › Editor/reviewer for publications (incl. CDCF T61 Journal Editor)
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Frontiers in Immunology (Journal)
CHONG, W. P. (Guest editor)
26 Jan 2024 → …Activity: Publication peer-review/editorial work › Editor/reviewer for publications (incl. CDCF T61 Journal Editor)
Press/Media
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Hong Kong young professor: Hong Kong young people have a lot of potential to be successful in mainland China
10/09/19
1 item of Media coverage
Press/Media