Synthesis, photophysical and biological studies of lanthanide complexes for photodynamic therapy

  • Yan Zhou

Student thesis: Doctoral Thesis

Abstract

1.2\xPrior to the PDT, we have also synthesized a series of water-soluble homoleptic lanthanides (Ln3+ = Gd, Er, and Yb) sandwich (DD) di-PEGylated porphyrin complexes. The Yb complex (YbDD) has shown the same NIR emission quantum yield as the highest record Yb complex in the literature (Yb-RhB), yet, the emission intensity is double compared to the Yb-N. This implies a new thinking about the quantity measurement for biological imaging. The brightness might be the prime factor for the development of luminescence in vitro/in vivo imaging agent rather than the emission quantum yield.

Date of Award14 Sep 2017
Original languageEnglish
SupervisorKa-Leung WONG (Supervisor)

User-Defined Keywords

  • Photochemotherapy
  • Rare earth metals
  • Analysis

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