Ytterbium(III) triflate catalyzed annulation of propargylic 1,4-diols with aryl sulfonamides to give highly substituted pyrrole derivatives

Xiaoxiang Zhang*, Jing Wei Teo, Edmond Dik Lung MA, Chung Hang Leung, Philip Wai Hong Chan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)

Abstract

A synthetic route to prepare highly substituted pyrrole derivatives efficiently in moderate to good yields via the Yb(OTf)3-catalyzed cyclization of 1,4-propargylic diols with aryl sulfonamides is reported herein. The present synthetic method offers an operationally simple and convenient route to pyrroles under mild conditions that does not require the exclusion of air and moisture.

Original languageEnglish
Pages (from-to)6703-6707
Number of pages5
JournalTetrahedron Letters
Volume55
Issue number49
DOIs
Publication statusPublished - 3 Dec 2014

Scopus Subject Areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

User-Defined Keywords

  • Homogeneous catalysis
  • Propargylic 1,4-diols
  • Pyrroles
  • Tandem reactions
  • Ytterbium(III) triflate

Fingerprint

Dive into the research topics of 'Ytterbium(III) triflate catalyzed annulation of propargylic 1,4-diols with aryl sulfonamides to give highly substituted pyrrole derivatives'. Together they form a unique fingerprint.

Cite this