Xanthones with growth inhibition against HeLa cells from Garcinia xipshuanbannaensis

Quan Bin Han; Nian Yun Yang; Hong Lei Tian; Chun Feng Qiao; Jing Zheng Song; Donald C. Chang; Shi Lin Chen; Kathy Q. Luo; Hong Xi Xu

doi:10.1016/j.phytochem.2008.05.019

Xanthones with growth inhibition against HeLa cells from Garcinia xipshuanbannaensis

Quan Bin Han
, Nian Yun Yang
, Hong Lei Tian
, Chun Feng Qiao
, Jing Zheng Song
, Donald C. Chang
, Shi Lin Chen
, Kathy Q. Luo^*
, Hong Xi Xu^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

94 Citations (Scopus)

Abstract

Eight prenylated xanthones, bannaxanthones A-H (1-8), together with seven known compounds, were isolated from the acetone extract of the twigs of Garcinia xipshuanbannaensis. Their structures were elucidated by spectroscopic data interpretation. The cytotoxic activities of these compounds were evaluated using the MTT method. The results showed that xanthones with an unsaturated prenyl group had stronger cytotoxic activity against cancer cells, whereas those with hydroxylated prenyl groups had none.

Original language	English
Pages (from-to)	2187-2192
Number of pages	6
Journal	Phytochemistry
Volume	69
Issue number	11
DOIs	https://doi.org/10.1016/j.phytochem.2008.05.019
Publication status	Published - Aug 2008

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

User-Defined Keywords

Bannaxanthones
Clusiaceae
Garcinia xipshuanbannaensis
Growth inhibition
HeLa cells
Xanthone

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10.1016/j.phytochem.2008.05.019

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@article{76283c4c631f4ec0884d20608f0c1ec4,

title = "Xanthones with growth inhibition against HeLa cells from Garcinia xipshuanbannaensis",

abstract = "Eight prenylated xanthones, bannaxanthones A-H (1-8), together with seven known compounds, were isolated from the acetone extract of the twigs of Garcinia xipshuanbannaensis. Their structures were elucidated by spectroscopic data interpretation. The cytotoxic activities of these compounds were evaluated using the MTT method. The results showed that xanthones with an unsaturated prenyl group had stronger cytotoxic activity against cancer cells, whereas those with hydroxylated prenyl groups had none.",

keywords = "Bannaxanthones, Clusiaceae, Garcinia xipshuanbannaensis, Growth inhibition, HeLa cells, Xanthone",

author = "Han, \{Quan Bin\} and Yang, \{Nian Yun\} and Tian, \{Hong Lei\} and Qiao, \{Chun Feng\} and Song, \{Jing Zheng\} and Chang, \{Donald C.\} and Chen, \{Shi Lin\} and Luo, \{Kathy Q.\} and Xu, \{Hong Xi\}",

note = "Funding Information: This research is funded by the Hong Kong Jockey Club Charities Trust.",

year = "2008",

month = aug,

doi = "10.1016/j.phytochem.2008.05.019",

language = "English",

volume = "69",

pages = "2187--2192",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Elsevier Ltd.",

number = "11",

}

TY - JOUR

T1 - Xanthones with growth inhibition against HeLa cells from Garcinia xipshuanbannaensis

AU - Han, Quan Bin

AU - Yang, Nian Yun

AU - Tian, Hong Lei

AU - Qiao, Chun Feng

AU - Song, Jing Zheng

AU - Chang, Donald C.

AU - Chen, Shi Lin

AU - Luo, Kathy Q.

AU - Xu, Hong Xi

N1 - Funding Information: This research is funded by the Hong Kong Jockey Club Charities Trust.

PY - 2008/8

Y1 - 2008/8

N2 - Eight prenylated xanthones, bannaxanthones A-H (1-8), together with seven known compounds, were isolated from the acetone extract of the twigs of Garcinia xipshuanbannaensis. Their structures were elucidated by spectroscopic data interpretation. The cytotoxic activities of these compounds were evaluated using the MTT method. The results showed that xanthones with an unsaturated prenyl group had stronger cytotoxic activity against cancer cells, whereas those with hydroxylated prenyl groups had none.

AB - Eight prenylated xanthones, bannaxanthones A-H (1-8), together with seven known compounds, were isolated from the acetone extract of the twigs of Garcinia xipshuanbannaensis. Their structures were elucidated by spectroscopic data interpretation. The cytotoxic activities of these compounds were evaluated using the MTT method. The results showed that xanthones with an unsaturated prenyl group had stronger cytotoxic activity against cancer cells, whereas those with hydroxylated prenyl groups had none.

KW - Bannaxanthones

KW - Clusiaceae

KW - Garcinia xipshuanbannaensis

KW - Growth inhibition

KW - HeLa cells

KW - Xanthone

UR - https://www.scopus.com/pages/publications/48049095481

U2 - 10.1016/j.phytochem.2008.05.019

DO - 10.1016/j.phytochem.2008.05.019

M3 - Journal article

SN - 0031-9422

VL - 69

SP - 2187

EP - 2192

JO - Phytochemistry

JF - Phytochemistry

IS - 11

ER -

Xanthones with growth inhibition against HeLa cells from Garcinia xipshuanbannaensis

Abstract

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