TY - JOUR
T1 - Weight reduction and cardiovascular benefits
T2 - Protocol for a systematic review and meta-analysis
AU - Zhao, Yingke
AU - Yu, Branda Yee Man
AU - Liu, Yanfei
AU - TONG, Tiejun
AU - Liu, Yue
N1 - Funding Information:
This work was supported by National Natural Science Foundation of China (no.81403266) and Beijing NOVA Program (No. Z171100001117027).
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Background: There is widespread obesity paradox in cardiovascular diseases, the cardiovascular influence from weight management remains controversial. Moreover, previous publications indicating that different weight reduction extent might lead to various results. Thus, it is of importance to reassess the cardiovascular benefits of weight management strategies. Objectives: This review is designed to assess the association between weight loss and cardiovascular outcomes. Methods: Clinical trials including randomized control trials, observational studies reported a weight change before and after weight interventions including lifestyle intervention, as well as pharmacotherapies were included. Three major databases will be searched to retrieve the appropriate studies. Dual selection and abstraction of data will be conducted by 2 authors independently. The population, intervention, comparator, outcomes, study characteristics framework will be used to extract all the necessary data from included studies. The risk of bias assessment will be conducted in duplicate based on the Cochrane risk of bias guideline for randomized controlled trials (RCTs) and the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement for observational studies respectively. The primary outcomes will be the cardiovascular mortality, and the secondary outcomes are allcause mortality and new cardiovascular events. A meta-analysis will be considered if there is sufficient homogeneity among selected studies. Follow the criteria of Grading of Recommendations, Assessment, Development and Evaluation (GRADE), the quality of the cumulative evidence will be evaluated. Resultsandconclusions: The results of this systematic review could provide reliable and concrete evidence for weight loss and its cardiovascular benefits. Prospero registration number: CRD42018108582.
AB - Background: There is widespread obesity paradox in cardiovascular diseases, the cardiovascular influence from weight management remains controversial. Moreover, previous publications indicating that different weight reduction extent might lead to various results. Thus, it is of importance to reassess the cardiovascular benefits of weight management strategies. Objectives: This review is designed to assess the association between weight loss and cardiovascular outcomes. Methods: Clinical trials including randomized control trials, observational studies reported a weight change before and after weight interventions including lifestyle intervention, as well as pharmacotherapies were included. Three major databases will be searched to retrieve the appropriate studies. Dual selection and abstraction of data will be conducted by 2 authors independently. The population, intervention, comparator, outcomes, study characteristics framework will be used to extract all the necessary data from included studies. The risk of bias assessment will be conducted in duplicate based on the Cochrane risk of bias guideline for randomized controlled trials (RCTs) and the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement for observational studies respectively. The primary outcomes will be the cardiovascular mortality, and the secondary outcomes are allcause mortality and new cardiovascular events. A meta-analysis will be considered if there is sufficient homogeneity among selected studies. Follow the criteria of Grading of Recommendations, Assessment, Development and Evaluation (GRADE), the quality of the cumulative evidence will be evaluated. Resultsandconclusions: The results of this systematic review could provide reliable and concrete evidence for weight loss and its cardiovascular benefits. Prospero registration number: CRD42018108582.
KW - Cardiovascular outcomes
KW - Obesity
KW - Systematic review
KW - Weight loss
UR - http://www.scopus.com/inward/record.url?scp=85058768927&partnerID=8YFLogxK
U2 - 10.1097/MD.0000000000013246
DO - 10.1097/MD.0000000000013246
M3 - Review article
C2 - 30557969
AN - SCOPUS:85058768927
SN - 0025-7974
VL - 97
JO - Medicine (United States)
JF - Medicine (United States)
IS - 50
M1 - e13246
ER -