Water soluble luminescent platinum terpyridine complexes with glycosylated acetylide and arylacetylide ligands: photoluminescent properties and cytotoxicities

Dik Lung Ma; Tina Yuen Ting Shum; Fuyi Zhang; Chi Ming Che; Mengsu Yang

doi:10.1039/b507114c

Water soluble luminescent platinum terpyridine complexes with glycosylated acetylide and arylacetylide ligands: photoluminescent properties and cytotoxicities

Dik Lung Ma
, Tina Yuen Ting Shum
, Fuyi Zhang
, Chi Ming Che^*
, Mengsu Yang

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

141 Citations (Scopus)

Abstract

Platinum(II) terpyridine complexes with glycosylated acetylide and arylacetylide ligands bind to DNA with binding constants ∼10⁵ mol⁻¹ dm³; the glycosylated arylacetylide complexes exhibit emission at λ_max ≈ 620 nm in water and are up to ∼100-times higher in potency than the clinical cisplatin drug in killing cancer cells.

Original language	English
Pages (from-to)	4675-4677
Number of pages	3
Journal	Chemical Communications
Issue number	37
Early online date	23 Aug 2005
DOIs	https://doi.org/10.1039/b507114c
Publication status	Published - 7 Oct 2005

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1039/b507114c

Cite this

@article{7af97457e02149b4adeddbefb9f0fbc1,

title = "Water soluble luminescent platinum terpyridine complexes with glycosylated acetylide and arylacetylide ligands: photoluminescent properties and cytotoxicities",

abstract = "Platinum(II) terpyridine complexes with glycosylated acetylide and arylacetylide ligands bind to DNA with binding constants ∼105 mol−1 dm3; the glycosylated arylacetylide complexes exhibit emission at λmax ≈ 620 nm in water and are up to ∼100-times higher in potency than the clinical cisplatin drug in killing cancer cells.",

author = "Ma, \{Dik Lung\} and Shum, \{Tina Yuen Ting\} and Fuyi Zhang and Che, \{Chi Ming\} and Mengsu Yang",

note = "Publisher copyright: {\textcopyright} The Royal Society of Chemistry 2005",

year = "2005",

month = oct,

day = "7",

doi = "10.1039/b507114c",

language = "English",

pages = "4675--4677",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "37",

}

TY - JOUR

T1 - Water soluble luminescent platinum terpyridine complexes with glycosylated acetylide and arylacetylide ligands

T2 - photoluminescent properties and cytotoxicities

AU - Ma, Dik Lung

AU - Shum, Tina Yuen Ting

AU - Zhang, Fuyi

AU - Che, Chi Ming

AU - Yang, Mengsu

PY - 2005/10/7

Y1 - 2005/10/7

N2 - Platinum(II) terpyridine complexes with glycosylated acetylide and arylacetylide ligands bind to DNA with binding constants ∼105 mol−1 dm3; the glycosylated arylacetylide complexes exhibit emission at λmax ≈ 620 nm in water and are up to ∼100-times higher in potency than the clinical cisplatin drug in killing cancer cells.

AB - Platinum(II) terpyridine complexes with glycosylated acetylide and arylacetylide ligands bind to DNA with binding constants ∼105 mol−1 dm3; the glycosylated arylacetylide complexes exhibit emission at λmax ≈ 620 nm in water and are up to ∼100-times higher in potency than the clinical cisplatin drug in killing cancer cells.

UR - https://www.scopus.com/pages/publications/26944494498

U2 - 10.1039/b507114c

DO - 10.1039/b507114c

M3 - Journal article

C2 - 16175289

AN - SCOPUS:26944494498

SN - 1359-7345

SP - 4675

EP - 4677

JO - Chemical Communications

JF - Chemical Communications

IS - 37

ER -

Water soluble luminescent platinum terpyridine complexes with glycosylated acetylide and arylacetylide ligands: photoluminescent properties and cytotoxicities

Abstract

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this