Water soluble luminescent platinum terpyridine complexes with glycosylated acetylide and arylacetylide ligands: photoluminescent properties and cytotoxicities

Dik Lung Ma; Tina Yuen Ting Shum; Fuyi Zhang; Chi Ming Che; Mengsu Yang

doi:10.1039/b507114c

Water soluble luminescent platinum terpyridine complexes with glycosylated acetylide and arylacetylide ligands: photoluminescent properties and cytotoxicities

Dik Lung Ma, Tina Yuen Ting Shum, Fuyi Zhang, Chi Ming Che^*, Mengsu Yang

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

135 Citations (Scopus)

Abstract

Platinum(II) terpyridine complexes with glycosylated acetylide and arylacetylide ligands bind to DNA with binding constants ∼10⁵ mol⁻¹ dm³; the glycosylated arylacetylide complexes exhibit emission at λ_max ≈ 620 nm in water and are up to ∼100-times higher in potency than the clinical cisplatin drug in killing cancer cells.

Original language	English
Pages (from-to)	4675-4677
Number of pages	3
Journal	Chemical Communications
Issue number	37
Early online date	23 Aug 2005
DOIs	https://doi.org/10.1039/b507114c
Publication status	Published - 7 Oct 2005

Scopus Subject Areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/b507114c

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title = "Water soluble luminescent platinum terpyridine complexes with glycosylated acetylide and arylacetylide ligands: photoluminescent properties and cytotoxicities",

abstract = "Platinum(II) terpyridine complexes with glycosylated acetylide and arylacetylide ligands bind to DNA with binding constants ∼105 mol−1 dm3; the glycosylated arylacetylide complexes exhibit emission at λmax ≈ 620 nm in water and are up to ∼100-times higher in potency than the clinical cisplatin drug in killing cancer cells.",

author = "Ma, {Dik Lung} and Shum, {Tina Yuen Ting} and Fuyi Zhang and Che, {Chi Ming} and Mengsu Yang",

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T1 - Water soluble luminescent platinum terpyridine complexes with glycosylated acetylide and arylacetylide ligands

T2 - photoluminescent properties and cytotoxicities

AU - Ma, Dik Lung

AU - Shum, Tina Yuen Ting

AU - Zhang, Fuyi

AU - Che, Chi Ming

AU - Yang, Mengsu

PY - 2005/10/7

Y1 - 2005/10/7

N2 - Platinum(II) terpyridine complexes with glycosylated acetylide and arylacetylide ligands bind to DNA with binding constants ∼105 mol−1 dm3; the glycosylated arylacetylide complexes exhibit emission at λmax ≈ 620 nm in water and are up to ∼100-times higher in potency than the clinical cisplatin drug in killing cancer cells.

AB - Platinum(II) terpyridine complexes with glycosylated acetylide and arylacetylide ligands bind to DNA with binding constants ∼105 mol−1 dm3; the glycosylated arylacetylide complexes exhibit emission at λmax ≈ 620 nm in water and are up to ∼100-times higher in potency than the clinical cisplatin drug in killing cancer cells.

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U2 - 10.1039/b507114c

DO - 10.1039/b507114c

M3 - Journal article

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AN - SCOPUS:26944494498

SN - 1359-7345

SP - 4675

EP - 4677

JO - Chemical Communications

JF - Chemical Communications

IS - 37

ER -

Water soluble luminescent platinum terpyridine complexes with glycosylated acetylide and arylacetylide ligands: photoluminescent properties and cytotoxicities

Abstract

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UN SDGs

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