@article{4089d04a37984368a80ee23ba1a88a9c,
title = "Volume segregation programming in a nematode's early embryogenesis",
abstract = "Nematode species are well-known for their invariant cell lineage pattern during development. Combining knowledge about the fate specification induced by asymmetric division and the anti-correlation between cell cycle length and cell volume in Caenorhabditis elegans, we propose a minimal model to simulate lineage initiation by altering cell volume segregation ratio in each division, and quantify the derived pattern's performance in proliferation speed, fate diversity, and space robustness. The stereotypic pattern in C. elegans embryo is found to be one of the most optimal solutions taking minimum time to achieve the cell number before gastrulation, by programming asymmetric divisions as a strategy.",
author = "Guoye Guan and Wong, {Ming Kin} and Zhongying Zhao and Tang, {Lei Han} and Chao Tang",
note = "Funding Information: We thank F. Liu, X. Yang, X. Kuang, K. Kong, and C. Luo for helpful discussions and comments. This work was supported by the National Natural Science Foundation of China (Grants No. 11635002, No. 12090053, No. 32088101, No. U1430237, and No. U1530401), the Hong Kong Research Grants Council (Grants No. HKBU12100118, No. HKBU12100917, No. HKBU12123716, No. HKBU12324716, and No. HKBU12301514), and the HKBU Interdisciplinary Research Cluster Fund. Computation was performed partly on the High-Performance Computing Platform at Peking University. Publisher Copyright: {\textcopyright} 2021 American Physical Society.",
year = "2021",
month = nov,
day = "23",
doi = "10.1103/PhysRevE.104.054409",
language = "English",
volume = "104",
journal = "Physical Review E",
issn = "2470-0045",
publisher = "American Physical Society",
number = "5",
}