Volume segregation programming in a nematode's early embryogenesis

Guoye Guan, Ming Kin Wong, Zhongying Zhao, Lei Han Tang, Chao Tang

Research output: Contribution to journalArticlepeer-review

Abstract

Nematode species are well-known for their invariant cell lineage pattern during development. Combining knowledge about the fate specification induced by asymmetric division and the anti-correlation between cell cycle length and cell volume in Caenorhabditis elegans, we propose a minimal model to simulate lineage initiation by altering cell volume segregation ratio in each division, and quantify the derived pattern's performance in proliferation speed, fate diversity, and space robustness. The stereotypic pattern in C. elegans embryo is found to be one of the most optimal solutions taking minimum time to achieve the cell number before gastrulation, by programming asymmetric divisions as a strategy.

Original languageEnglish
Article number054409
JournalPhysical Review E
Volume104
Issue number5
DOIs
Publication statusPublished - 23 Nov 2021

Scopus Subject Areas

  • Statistical and Nonlinear Physics
  • Statistics and Probability
  • Condensed Matter Physics

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