Volume segregation programming in a nematode's early embryogenesis

Guoye Guan; Ming Kin Wong; Zhongying Zhao; Lei Han Tang; Chao Tang

doi:10.1103/PhysRevE.104.054409

Volume segregation programming in a nematode's early embryogenesis

Guoye Guan, Ming Kin Wong, Zhongying Zhao, Lei Han Tang^*, Chao Tang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Nematode species are well-known for their invariant cell lineage pattern during development. Combining knowledge about the fate specification induced by asymmetric division and the anti-correlation between cell cycle length and cell volume in Caenorhabditis elegans, we propose a minimal model to simulate lineage initiation by altering cell volume segregation ratio in each division, and quantify the derived pattern's performance in proliferation speed, fate diversity, and space robustness. The stereotypic pattern in C. elegans embryo is found to be one of the most optimal solutions taking minimum time to achieve the cell number before gastrulation, by programming asymmetric divisions as a strategy.

Original language	English
Article number	054409
Number of pages	5
Journal	Physical Review E
Volume	104
Issue number	5
DOIs	https://doi.org/10.1103/PhysRevE.104.054409
Publication status	Published - 23 Nov 2021

Scopus Subject Areas

Statistical and Nonlinear Physics
Statistics and Probability
Condensed Matter Physics

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title = "Volume segregation programming in a nematode's early embryogenesis",

abstract = "Nematode species are well-known for their invariant cell lineage pattern during development. Combining knowledge about the fate specification induced by asymmetric division and the anti-correlation between cell cycle length and cell volume in Caenorhabditis elegans, we propose a minimal model to simulate lineage initiation by altering cell volume segregation ratio in each division, and quantify the derived pattern's performance in proliferation speed, fate diversity, and space robustness. The stereotypic pattern in C. elegans embryo is found to be one of the most optimal solutions taking minimum time to achieve the cell number before gastrulation, by programming asymmetric divisions as a strategy.",

author = "Guoye Guan and Wong, {Ming Kin} and Zhongying Zhao and Tang, {Lei Han} and Chao Tang",

note = "Funding Information: We thank F. Liu, X. Yang, X. Kuang, K. Kong, and C. Luo for helpful discussions and comments. This work was supported by the National Natural Science Foundation of China (Grants No. 11635002, No. 12090053, No. 32088101, No. U1430237, and No. U1530401), the Hong Kong Research Grants Council (Grants No. HKBU12100118, No. HKBU12100917, No. HKBU12123716, No. HKBU12324716, and No. HKBU12301514), and the HKBU Interdisciplinary Research Cluster Fund. Computation was performed partly on the High-Performance Computing Platform at Peking University. Publisher Copyright: {\textcopyright} 2021 American Physical Society.",

year = "2021",

month = nov,

day = "23",

doi = "10.1103/PhysRevE.104.054409",

language = "English",

volume = "104",

journal = "Physical Review E",

issn = "2470-0045",

publisher = "American Physical Society",

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T1 - Volume segregation programming in a nematode's early embryogenesis

AU - Guan, Guoye

AU - Wong, Ming Kin

AU - Zhao, Zhongying

AU - Tang, Lei Han

AU - Tang, Chao

N1 - Funding Information: We thank F. Liu, X. Yang, X. Kuang, K. Kong, and C. Luo for helpful discussions and comments. This work was supported by the National Natural Science Foundation of China (Grants No. 11635002, No. 12090053, No. 32088101, No. U1430237, and No. U1530401), the Hong Kong Research Grants Council (Grants No. HKBU12100118, No. HKBU12100917, No. HKBU12123716, No. HKBU12324716, and No. HKBU12301514), and the HKBU Interdisciplinary Research Cluster Fund. Computation was performed partly on the High-Performance Computing Platform at Peking University. Publisher Copyright: © 2021 American Physical Society.

PY - 2021/11/23

Y1 - 2021/11/23

N2 - Nematode species are well-known for their invariant cell lineage pattern during development. Combining knowledge about the fate specification induced by asymmetric division and the anti-correlation between cell cycle length and cell volume in Caenorhabditis elegans, we propose a minimal model to simulate lineage initiation by altering cell volume segregation ratio in each division, and quantify the derived pattern's performance in proliferation speed, fate diversity, and space robustness. The stereotypic pattern in C. elegans embryo is found to be one of the most optimal solutions taking minimum time to achieve the cell number before gastrulation, by programming asymmetric divisions as a strategy.

AB - Nematode species are well-known for their invariant cell lineage pattern during development. Combining knowledge about the fate specification induced by asymmetric division and the anti-correlation between cell cycle length and cell volume in Caenorhabditis elegans, we propose a minimal model to simulate lineage initiation by altering cell volume segregation ratio in each division, and quantify the derived pattern's performance in proliferation speed, fate diversity, and space robustness. The stereotypic pattern in C. elegans embryo is found to be one of the most optimal solutions taking minimum time to achieve the cell number before gastrulation, by programming asymmetric divisions as a strategy.

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U2 - 10.1103/PhysRevE.104.054409

DO - 10.1103/PhysRevE.104.054409

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SN - 2470-0045

VL - 104

JO - Physical Review E

JF - Physical Review E

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ER -

Volume segregation programming in a nematode's early embryogenesis

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