@article{fb0c2a3fc91e4208b457351c48c6f32f,
title = "Vitexlactam A, a novel labdane diterpene lactam from the fruits of Vitex agnus-castus",
abstract = "A novel labdane diterpene alkaloid, vitexlactam A (1) was isolated as a prism from the n-hexane extract of the fruits of Vitex agnus-castus through normal and reverse phase column chromatography. Its structure was elucidated to be 6β-acetoxy-9α-hydroxy-13(14)-labden-16,15-amide, based on chemical and spectral evidences including 1D and 2D NMR spectra. The structure was confirmed by X-ray crystallographic analysis. Compound 1 is the first naturally occurring labdane diterpenoid containing an α,β-unsaturated γ-lactam moiety.",
keywords = "Labdane diterpene, Lactam, NMR, Verbenaceae, Vitex agnus-castus, Vitexlactam A, X-ray",
author = "Li, {Sheng Hong} and Hongjie Zhang and Qiu, {Sheng Xiang} and Niu, {Xue Mei} and Santarsiero, {Bernard D.} and Mesecar, {Andrew D.} and Fong, {Harry H.S.} and Farnsworth, {Norman R.} and Sun, {Han Dong}",
note = "Funding Information: The authors wish to thank the members of the analytical group of Phytochemistry Laboratory of Kunming Institute of Botany, Academic Sinica, for measurements of the NMR, MS, IR, UV and ORD spectral data, and Dr. Phillip E. Fanwick from the Department of Chemistry, Purdue University, for collecting the X-ray diffraction data. X-Ray analysis was made possible through partial funding by grant P50 AT00155 through the National Center for Complementary and Alternative Medicine (NCCAM), the Office of Dietary Supplements (ODS), the National Institute of General Medicine (NIGMS), and the Office for Research on Women's Health (ORWH). Contents are solely the responsibility of the authors and do not necessarily represent the official views of NCCAM, ODS, NIGMS, or ORWH.",
year = "2002",
month = jul,
day = "15",
doi = "10.1016/S0040-4039(02)00981-4",
language = "English",
volume = "43",
pages = "5131--5134",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Ltd.",
number = "29",
}