Visualization of Zn2+ ions in live zebrafish using a luminescent iridium(III) chemosensor

Edmond Dik Lung MA*, Hong Zhang He, Hai Jing Zhong, Sheng Lin, Daniel Shiu Hin Chan, Liang Wang, Simon Ming Yuen Lee, Chung Hang Leung, Chun Yuen Wong

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)

Abstract

A novel luminescent cyclometalated iridium(III) complex-based chemosensor (1) bearing a zinc-specific receptor, tris(2-pyridylmethyl)amine, and the 3-phenyl-1H-pyrazole ligand has been designed and synthesized. Upon the addition of Zn2+ ions to a solution of iridium(III) complex 1, a pronounced luminescence color change from blue to green can be observed, which may be attributed to the suppression of photoinduced electron transfer upon complexation of complex 1 with Zn2+ ions. The interaction of iridium(III) complex 1 with Zn2+ ions was investigated by UV-vis absorption titration, emission titration, and 1H NMR titration. Furthermore, the iridium(III) complex 1 exhibited good selectivity for Zn 2+ over 13 other common metal ions, including K+, Ag +, Na+, Ni2+, Fe3+, Hg2+, Cd2+, Mg2+, Ca2+, Cu2+, Mn 2+, Co2+, and Pb2+ ions. The practical application of the iridium(III) complex 1 in visualizing intracellular Zn 2+ distribution in live zebrafish was also demonstrated.

Original languageEnglish
Pages (from-to)14008-14015
Number of pages8
JournalACS applied materials & interfaces
Volume6
Issue number16
DOIs
Publication statusPublished - 27 Aug 2014

Scopus Subject Areas

  • Materials Science(all)

User-Defined Keywords

  • chemosensor
  • iridium(III) complex
  • luminescent
  • zinc ion

Fingerprint

Dive into the research topics of 'Visualization of Zn<sup>2+</sup> ions in live zebrafish using a luminescent iridium(III) chemosensor'. Together they form a unique fingerprint.

Cite this