Visualization of Hypoxic Tumors: Stimulated by NIR-IIb Emissive Erbium(III)-Phthalocyaninate Nanoagent

Jingru Feng; Weirui Zhu; Wei Wei; Wanqi Zhou; Wai Sum Lo; Xipeng Li; Zongwen Tan; Xueyang Fang; Wai Kwok Wong; Ka Leung Wong; Tao Zhang

doi:10.1021/acs.analchem.5c02811

Visualization of Hypoxic Tumors: Stimulated by NIR-IIb Emissive Erbium(III)-Phthalocyaninate Nanoagent

Jingru Feng
, Weirui Zhu
, Wei Wei
, Wanqi Zhou
, Wai Sum Lo
, Xipeng Li
, Zongwen Tan
, Xueyang Fang
, Wai Kwok Wong
, Ka Leung Wong^*
, Tao Zhang^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

1 Citation (Scopus)

Abstract

This study presents a long-lived NIR-IIb luminogenic nanoagent (ErPc-Sa NPs) based on a newly designed erbium phthalocyaninate complex with impressive quantum yield at 1530 nm (Er, 2.81%) via single molecular self-assembly; NIR-IIb (1500–1700 nm) imaging holds tremendous potential for targeted screening of deep-seated pathological changes in tissues, though developing activatable NIR-IIb probes has been challenging. The luminescence of the nanoagent is switched on at 1530 nm upon activation by carbonic anhydrase (CA), a hypoxic tumor marker, under 680 nm excitation. ErPc-Sa NPs shows high specificity toward CA on MDA-MB-231 cell membranes under hypoxic conditions and the localized CA in tumor-bearing mice with NIR-IIb imaging.

Original language	English
Pages (from-to)	14894-14898
Number of pages	5
Journal	Analytical Chemistry
Volume	97
Issue number	28
Early online date	10 Jul 2025
DOIs	https://doi.org/10.1021/acs.analchem.5c02811
Publication status	Published - 22 Jul 2025

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10.1021/acs.analchem.5c02811

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@article{a4403e25b56b45b19923fd8dd3aef732,

title = "Visualization of Hypoxic Tumors: Stimulated by NIR-IIb Emissive Erbium(III)-Phthalocyaninate Nanoagent",

abstract = "This study presents a long-lived NIR-IIb luminogenic nanoagent (ErPc-Sa NPs) based on a newly designed erbium phthalocyaninate complex with impressive quantum yield at 1530 nm (Er, 2.81\%) via single molecular self-assembly; NIR-IIb (1500–1700 nm) imaging holds tremendous potential for targeted screening of deep-seated pathological changes in tissues, though developing activatable NIR-IIb probes has been challenging. The luminescence of the nanoagent is switched on at 1530 nm upon activation by carbonic anhydrase (CA), a hypoxic tumor marker, under 680 nm excitation. ErPc-Sa NPs shows high specificity toward CA on MDA-MB-231 cell membranes under hypoxic conditions and the localized CA in tumor-bearing mice with NIR-IIb imaging.",

author = "Jingru Feng and Weirui Zhu and Wei Wei and Wanqi Zhou and Lo, \{Wai Sum\} and Xipeng Li and Zongwen Tan and Xueyang Fang and Wong, \{Wai Kwok\} and Wong, \{Ka Leung\} and Tao Zhang",

note = "Publisher Copyright: {\textcopyright} 2025 American Chemical Society. Funding Information: This research was supported by the National Natural Science Foundation of China (52372148), the Natural Science Foundation of Guangdong (2023A1515010262), the Major Program of Ningbo Science and Technology Innovation 2025 (2020Z093), Zhejiang Province, China and the RGC Areas of Excellence (AoE) Scheme (AoE/M-401/20). The Open Fund of Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates (2023B1212060003).",

year = "2025",

month = jul,

day = "22",

doi = "10.1021/acs.analchem.5c02811",

language = "English",

volume = "97",

pages = "14894--14898",

journal = "Analytical Chemistry",

issn = "0003-2700",

publisher = "American Chemical Society",

number = "28",

}

TY - JOUR

T1 - Visualization of Hypoxic Tumors

T2 - Stimulated by NIR-IIb Emissive Erbium(III)-Phthalocyaninate Nanoagent

AU - Feng, Jingru

AU - Zhu, Weirui

AU - Wei, Wei

AU - Zhou, Wanqi

AU - Lo, Wai Sum

AU - Li, Xipeng

AU - Tan, Zongwen

AU - Fang, Xueyang

AU - Wong, Wai Kwok

AU - Wong, Ka Leung

AU - Zhang, Tao

N1 - Publisher Copyright: © 2025 American Chemical Society. Funding Information: This research was supported by the National Natural Science Foundation of China (52372148), the Natural Science Foundation of Guangdong (2023A1515010262), the Major Program of Ningbo Science and Technology Innovation 2025 (2020Z093), Zhejiang Province, China and the RGC Areas of Excellence (AoE) Scheme (AoE/M-401/20). The Open Fund of Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates (2023B1212060003).

PY - 2025/7/22

Y1 - 2025/7/22

N2 - This study presents a long-lived NIR-IIb luminogenic nanoagent (ErPc-Sa NPs) based on a newly designed erbium phthalocyaninate complex with impressive quantum yield at 1530 nm (Er, 2.81%) via single molecular self-assembly; NIR-IIb (1500–1700 nm) imaging holds tremendous potential for targeted screening of deep-seated pathological changes in tissues, though developing activatable NIR-IIb probes has been challenging. The luminescence of the nanoagent is switched on at 1530 nm upon activation by carbonic anhydrase (CA), a hypoxic tumor marker, under 680 nm excitation. ErPc-Sa NPs shows high specificity toward CA on MDA-MB-231 cell membranes under hypoxic conditions and the localized CA in tumor-bearing mice with NIR-IIb imaging.

AB - This study presents a long-lived NIR-IIb luminogenic nanoagent (ErPc-Sa NPs) based on a newly designed erbium phthalocyaninate complex with impressive quantum yield at 1530 nm (Er, 2.81%) via single molecular self-assembly; NIR-IIb (1500–1700 nm) imaging holds tremendous potential for targeted screening of deep-seated pathological changes in tissues, though developing activatable NIR-IIb probes has been challenging. The luminescence of the nanoagent is switched on at 1530 nm upon activation by carbonic anhydrase (CA), a hypoxic tumor marker, under 680 nm excitation. ErPc-Sa NPs shows high specificity toward CA on MDA-MB-231 cell membranes under hypoxic conditions and the localized CA in tumor-bearing mice with NIR-IIb imaging.

UR - https://www.scopus.com/pages/publications/105010297109

U2 - 10.1021/acs.analchem.5c02811

DO - 10.1021/acs.analchem.5c02811

M3 - Journal article

AN - SCOPUS:105010297109

SN - 0003-2700

VL - 97

SP - 14894

EP - 14898

JO - Analytical Chemistry

JF - Analytical Chemistry

IS - 28

ER -

Visualization of Hypoxic Tumors: Stimulated by NIR-IIb Emissive Erbium(III)-Phthalocyaninate Nanoagent

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