Abstract
An efficient and visible light-promoted cascade N-alkylation/amidation of quinazolin-4(3H)-ones with benzyl halides and allyl halides has been described for the first time to provide a convenient access to quinazoline-2,4(1H,3H)-diones. This cascade N-alkylation/amidation reaction shows good functional group tolerance and could also be applied to N-heterocycles such as benzo[d]thiazoles, benzo[d]imidazoles, and quinazolines. Control experiments show that K2CO3 plays an important role in this transformation.
Original language | English |
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Pages (from-to) | 2423-2428 |
Number of pages | 6 |
Journal | Organic and Biomolecular Chemistry |
Volume | 21 |
Issue number | 11 |
Early online date | 27 Feb 2023 |
DOIs | |
Publication status | Published - 21 Mar 2023 |
Scopus Subject Areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry