Viral Interleukin-10 Expressed by Human Cytomegalovirus during the Latent Phase of Infection Modulates Latently Infected Myeloid Cell Differentiation

Selmir Avdic, John Z. Cao, Allen K. L. Cheung, Allison Abendroth, Barry Slobedman*

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

43 Citations (Scopus)

Abstract

The human cytomegalovirus UL111A gene is expressed during latent and productive infections, and it codes for homologs of interleukin-10 (IL-10). We examined whether viral IL-10 expressed during latency altered differentiation of latently infected myeloid progenitors. In comparison to infection with parental virus or mock infection, latent infection with a virus in which the gene encoding viral IL-10 has been deleted upregulated cytokines associated with dendritic cell (DC) formation and increased the proportion of myeloid DCs. These data demonstrate that viral IL-10 restricts the ability of latently infected myeloid progenitors to differentiate into DCs and identifies an immunomodulatory role for viral IL-10 which may limit the host's ability to clear latent virus.

Original languageEnglish
Pages (from-to)7465-7471
Number of pages7
JournalJournal of Virology
Volume85
Issue number14
DOIs
Publication statusPublished - 15 Jul 2011

Scopus Subject Areas

  • Microbiology
  • Immunology
  • Insect Science
  • Virology

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