@article{9af57be04f314314a9c8a3cb1fa4632c,
title = "Viral Interleukin-10 Expressed by Human Cytomegalovirus during the Latent Phase of Infection Modulates Latently Infected Myeloid Cell Differentiation",
abstract = "The human cytomegalovirus UL111A gene is expressed during latent and productive infections, and it codes for homologs of interleukin-10 (IL-10). We examined whether viral IL-10 expressed during latency altered differentiation of latently infected myeloid progenitors. In comparison to infection with parental virus or mock infection, latent infection with a virus in which the gene encoding viral IL-10 has been deleted upregulated cytokines associated with dendritic cell (DC) formation and increased the proportion of myeloid DCs. These data demonstrate that viral IL-10 restricts the ability of latently infected myeloid progenitors to differentiate into DCs and identifies an immunomodulatory role for viral IL-10 which may limit the host's ability to clear latent virus.",
author = "Selmir Avdic and Cao, {John Z.} and Cheung, {Allen K. L.} and Allison Abendroth and Barry Slobedman",
note = "Funding information: We thank Bodo Plachter and Sandra Pepperl-Klindworth (Institute for Virology, University Medical Center of the University of Mainz) for kindly providing the viral IL-10 deletion and parental viruses and Eve Diefenbach and Winnie Garcia (Westmead Millennium Institute) for assistance in generating recombinant viral IL-10 proteins. Flow cytometry was performed in the Flow Cytometry Core Facility that is supported by Westmead Millennium Institute, Australian National Health and Medical Research Council (NHMRC), and Cancer Institute New South Wales. S.A. and J.Z.C. were recipients of an Australian Postgraduate Award and a Westmead Medical Research Foundation Stipend Enhancement Award. This work was supported by NHMRC grant funding awarded to B.S. and A.A. Publisher copyright: {\textcopyright} 2011 American Society for Microbiology.",
year = "2011",
month = jul,
day = "15",
doi = "10.1128/JVI.00088-11",
language = "English",
volume = "85",
pages = "7465--7471",
journal = "Journal of Virology",
issn = "0022-538X",
publisher = "American Society for Microbiology",
number = "14",
}