Validation of the Interaction Between Stress-Responsive LncRNAs and RNA-Binding Proteins In Vitro

Liaoliao Ye, Tao Qin, Liming Xiong*

*Corresponding author for this work

Research output: Chapter in book/report/conference proceedingChapterpeer-review

1 Citation (Scopus)

Abstract

Plant long non-coding RNAs (lncRNAs) have been implicated in many biological processes, including responses to abiotic stresses, yet their detailed functions and especially their modes of action are still underexplored. lncRNAs often interact with proteins to participate in multiple levels of gene regulation. Therefore, identifying the RNA-binding proteins and validating their interaction with lncRNAs will be instrumental in revealing the functions of lncRNAs. Here, we describe two major methods to determine the interaction between lncRNA and proteins in vitro, RNA pull-down, and RNA EMSA.
Original languageEnglish
Title of host publicationPlant Stress Tolerance
Subtitle of host publicationMethods and Protocols
EditorsRamanjulu Sunkar
Place of PublicationNew York
PublisherHumana Press Inc.
Pages133-144
Number of pages12
Edition3rd
ISBN (Electronic)9781071639733
ISBN (Print)9781071639726, 9781071639757
DOIs
Publication statusPublished - 13 Jun 2024

Publication series

NameMethods in Molecular Biology
Volume2832
ISSN (Print)1064-3745
ISSN (Electronic)1940-6029

Scopus Subject Areas

  • Molecular Biology
  • Genetics

User-Defined Keywords

  • LncRNA
  • RNA EMSA
  • RNA pull-down
  • RNA-binding protein

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