Validating a functional near-infrared spectroscopy diagnostic paradigm for Major Depressive Disorder

Syeda Fabeha Husain; Rongjun YU; Tong Boon Tang; Wilson W. Tam; Bach Tran; Travis T. Quek; Shi Hui Hwang; Cheryl W. Chang; Cyrus S. Ho; Roger C. Ho

doi:10.1038/s41598-020-66784-2

Validating a functional near-infrared spectroscopy diagnostic paradigm for Major Depressive Disorder

Syeda Fabeha Husain, Rongjun YU, Tong Boon Tang, Wilson W. Tam, Bach Tran, Travis T. Quek, Shi Hui Hwang, Cheryl W. Chang, Cyrus S. Ho, Roger C. Ho^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

180 Citations (Scopus)

Abstract

Reduced haemodynamic response in the frontotemporal cortices of patients with major depressive disorder (MDD) has been demonstrated using functional near-infrared spectroscopy (fNIRS). Most notably, changes in cortical oxy-haemoglobin during a Japanese phonetic fluency task can differentiate psychiatric patients from healthy controls (HC). However, this paradigm has not been validated in the English language. Therefore, the present work aimed to distinguish patients with MDD from HCs, using haemodynamic response measured during an English letter fluency task. One hundred and five HCs and 105 patients with MDD took part in this study. NIRS signals during the verbal fluency task (VFT) was acquired using a 52-channel system, and changes in oxy-haemoglobin in the frontal and temporal regions were quantified. Depression severity, psychosocial functioning, pharmacotherapy and psychiatric history were noted. Patients with MDD had smaller changes in oxy-haemoglobin in the frontal and temporal cortices than HCs. In both regions of interest, oxy-haemoglobin was not associated with any of the clinical variables studied. 75.2% and 76.5% of patients with MDD were correctly classified using frontal and temporal region oxy-haemoglobin, respectively. Haemodynamic response measured by fNIRS during an English letter fluency task is a promising biomarker for MDD.

Original language	English
Article number	9740
Journal	Scientific Reports
Volume	10
Issue number	1
DOIs	https://doi.org/10.1038/s41598-020-66784-2
Publication status	Published - 1 Dec 2020

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title = "Validating a functional near-infrared spectroscopy diagnostic paradigm for Major Depressive Disorder",

abstract = "Reduced haemodynamic response in the frontotemporal cortices of patients with major depressive disorder (MDD) has been demonstrated using functional near-infrared spectroscopy (fNIRS). Most notably, changes in cortical oxy-haemoglobin during a Japanese phonetic fluency task can differentiate psychiatric patients from healthy controls (HC). However, this paradigm has not been validated in the English language. Therefore, the present work aimed to distinguish patients with MDD from HCs, using haemodynamic response measured during an English letter fluency task. One hundred and five HCs and 105 patients with MDD took part in this study. NIRS signals during the verbal fluency task (VFT) was acquired using a 52-channel system, and changes in oxy-haemoglobin in the frontal and temporal regions were quantified. Depression severity, psychosocial functioning, pharmacotherapy and psychiatric history were noted. Patients with MDD had smaller changes in oxy-haemoglobin in the frontal and temporal cortices than HCs. In both regions of interest, oxy-haemoglobin was not associated with any of the clinical variables studied. 75.2% and 76.5% of patients with MDD were correctly classified using frontal and temporal region oxy-haemoglobin, respectively. Haemodynamic response measured by fNIRS during an English letter fluency task is a promising biomarker for MDD.",

author = "Husain, {Syeda Fabeha} and Rongjun YU and Tang, {Tong Boon} and Tam, {Wilson W.} and Bach Tran and Quek, {Travis T.} and Hwang, {Shi Hui} and Chang, {Cheryl W.} and Ho, {Cyrus S.} and Ho, {Roger C.}",

note = "Funding Information: The authors would like to thank all study participants and Hitachi Medical Systems Singapore for their in-kind contribution of the ETG-4000 system. This study was funded by NUS iHeathtech Other Operating Expenses (R-722-000-004-731), the Ministry of Education under HICOE scheme to CISIR, UTP, and the Vingroup Innovation Foundation in project code VINIF.2019.DA14.",

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AU - Husain, Syeda Fabeha

AU - YU, Rongjun

AU - Tang, Tong Boon

AU - Tam, Wilson W.

AU - Tran, Bach

AU - Quek, Travis T.

AU - Hwang, Shi Hui

AU - Chang, Cheryl W.

AU - Ho, Cyrus S.

AU - Ho, Roger C.

N1 - Funding Information: The authors would like to thank all study participants and Hitachi Medical Systems Singapore for their in-kind contribution of the ETG-4000 system. This study was funded by NUS iHeathtech Other Operating Expenses (R-722-000-004-731), the Ministry of Education under HICOE scheme to CISIR, UTP, and the Vingroup Innovation Foundation in project code VINIF.2019.DA14.

PY - 2020/12/1

Y1 - 2020/12/1

N2 - Reduced haemodynamic response in the frontotemporal cortices of patients with major depressive disorder (MDD) has been demonstrated using functional near-infrared spectroscopy (fNIRS). Most notably, changes in cortical oxy-haemoglobin during a Japanese phonetic fluency task can differentiate psychiatric patients from healthy controls (HC). However, this paradigm has not been validated in the English language. Therefore, the present work aimed to distinguish patients with MDD from HCs, using haemodynamic response measured during an English letter fluency task. One hundred and five HCs and 105 patients with MDD took part in this study. NIRS signals during the verbal fluency task (VFT) was acquired using a 52-channel system, and changes in oxy-haemoglobin in the frontal and temporal regions were quantified. Depression severity, psychosocial functioning, pharmacotherapy and psychiatric history were noted. Patients with MDD had smaller changes in oxy-haemoglobin in the frontal and temporal cortices than HCs. In both regions of interest, oxy-haemoglobin was not associated with any of the clinical variables studied. 75.2% and 76.5% of patients with MDD were correctly classified using frontal and temporal region oxy-haemoglobin, respectively. Haemodynamic response measured by fNIRS during an English letter fluency task is a promising biomarker for MDD.

AB - Reduced haemodynamic response in the frontotemporal cortices of patients with major depressive disorder (MDD) has been demonstrated using functional near-infrared spectroscopy (fNIRS). Most notably, changes in cortical oxy-haemoglobin during a Japanese phonetic fluency task can differentiate psychiatric patients from healthy controls (HC). However, this paradigm has not been validated in the English language. Therefore, the present work aimed to distinguish patients with MDD from HCs, using haemodynamic response measured during an English letter fluency task. One hundred and five HCs and 105 patients with MDD took part in this study. NIRS signals during the verbal fluency task (VFT) was acquired using a 52-channel system, and changes in oxy-haemoglobin in the frontal and temporal regions were quantified. Depression severity, psychosocial functioning, pharmacotherapy and psychiatric history were noted. Patients with MDD had smaller changes in oxy-haemoglobin in the frontal and temporal cortices than HCs. In both regions of interest, oxy-haemoglobin was not associated with any of the clinical variables studied. 75.2% and 76.5% of patients with MDD were correctly classified using frontal and temporal region oxy-haemoglobin, respectively. Haemodynamic response measured by fNIRS during an English letter fluency task is a promising biomarker for MDD.

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Validating a functional near-infrared spectroscopy diagnostic paradigm for Major Depressive Disorder

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