Utilization of G-Quadruplex-Forming Aptamers for the Construction of Luminescence Sensing Platforms

Edmond Dik Lung MA*, Wanhe Wang, Zhifeng Mao, Tian Shu Kang, Simon Q B HAN, Philip Wai Hong Chan, Chung Hang Leung

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

28 Citations (Scopus)

Abstract

Aptamers are nucleic acid sequences that can recognize and bind to analytes with high affinity and selectivity. Intriguingly, a number of aptamers undergo a conformational change within the G-quadruplex motif upon ligand binding. This Minireview aims to highlight interesting examples of luminescent G-quadruplex aptamer-based probes that have been developed in recent years. Various mechanisms and sensing modes are described, and the outlook and future directions of this field are also discussed.

Original languageEnglish
Pages (from-to)8-17
Number of pages10
JournalChemPlusChem
Volume82
Issue number1
DOIs
Publication statusPublished - 1 Jan 2017

Scopus Subject Areas

  • Chemistry(all)

User-Defined Keywords

  • aptamers
  • G-quadruplexes
  • luminescence
  • oligonucleotides
  • sensors

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