Abstract
High-performance liquid chromatography with diode-array detection has been used to evaluate the quality of Erxian decoction (EXD), a Chinese medicine prescription, by use of a combination of fingerprinting and simultaneous quantification of six marker compounds. The standard chromatographic fingerprint containing forty common peaks was constructed from seven batches of the EXD samples to evaluate batch-to-batch consistency. In addition, six representative bioactive markers were simultaneously quantified with good linearity, precision, repeatability, and accuracy. The fingerprint accompanied by quantification of the marker compounds can be used to evaluate the quality of EXD.
Original language | English |
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Pages (from-to) | 613-618 |
Number of pages | 6 |
Journal | Chromatographia |
Volume | 70 |
Issue number | 3-4 |
DOIs | |
Publication status | Published - Aug 2009 |
User-Defined Keywords
- Column liquid chromatography
- Diode-array detection
- Erxian decoction
- Traditional Chinese medicine
- Quality evaluation
- Fingerprint
- Consistency