Upconversion Nanoparticle-Mediated Optogenetics

Zhigao Yi, Angelo Homayoun ALL, Xiaogang Liu*

*Corresponding author for this work

Research output: Chapter in book/report/conference proceedingChapterpeer-review

6 Citations (Scopus)


Upconversion nanoparticle-mediated optogenetics enables remote delivery of upconverted visible light from a near-infrared light source to targeted neurons or areas, with the precision of a pulse of laser light in vivo for effective deep-tissue neuromodulation. Compared to conventional optogenetic tools, upconversion nanoparticle-based optogenetic techniques are less invasive and cause reduced inflammation with minimal levels of tissue damage. In addition to the optical stimulation, this design offers simultaneously temperature recording in proximity to the stimulated area. This chapter strives to provide life science researchers with an introduction to upconversion optogenetics, starting from the fundamental concept of photon upconversion and nanoparticle fabrication to the current state-of-the-art of surface engineering and device integration for minimally invasive neuromodulation.

Original languageEnglish
Title of host publicationOptogenetics
Subtitle of host publicationLight-Sensing Proteins and Their Applications in Neuroscience and Beyond
EditorsHiromu Yawo, Hideki Kandori, Amane Koizumi, Ryoichiro Kageyama
PublisherSpringer Singapore
Number of pages17
ISBN (Electronic)9789811587634
ISBN (Print)9789811587627, 9789811587658
Publication statusPublished - 6 Jan 2021

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598
ISSN (Electronic)2214-8019

Scopus Subject Areas

  • Biochemistry, Genetics and Molecular Biology(all)

User-Defined Keywords

  • Infrared Rays
  • Nanoparticles
  • Neurons
  • Optogenetics
  • Photons


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