Pyrroles have been efficiently synthesised by a three-step reaction sequence. Michael addition of keto esters onto phenyl vinyl sulfoxide followed by Pummerer rearrangement gave the cyclic key intermediate 3. Mercury(II) salt induced carbon-sulfur bond cleavage afforded a 1,4-dicarbonyl equivalent 5. Treatment of the latter with an ammonium salt or a primary amine led to substituted pyrroles.
|Number of pages||2|
|Journal||Journal of the Chemical Society, Perkin Transactions 1|
|Publication status||Published - 1994|
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