Unfolded protein response is required for the definitive endodermal specification of mouse embryonic stem cells via Smad2 and βS-catenin signaling

Huiming Xu; Kam Sze Tsang; Yonghui Wang; Juliana C.N. Chan; Gang Xu; Wei Qiang Gao

doi:10.1074/jbc.M114.572560

Unfolded protein response is required for the definitive endodermal specification of mouse embryonic stem cells via Smad2 and βS-catenin signaling

Huiming Xu
, Kam Sze Tsang
, Yonghui Wang
, Juliana C.N. Chan
, Gang Xu^*
, Wei Qiang Gao

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

32 Citations (Scopus)

Abstract

Background: The unfolded protein response (UPR) influences cellular differentiation and function.

Results: UPR-inducing agents enhance the differentiation of definitive endoderm cells from mouse ESCs. Inhibition of the UPR prevents the specific differentiation.

Conclusion: The UPR is required for the formation of definitive endoderm cells.

Significance: This study identifies a new molecular mechanism that interconnects the UPR and cell fate decisions in early embryonic development.

Original language	English
Pages (from-to)	26290-26301
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	289
Issue number	38
DOIs	https://doi.org/10.1074/jbc.M114.572560
Publication status	Published - 19 Sept 2014

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SDG 3 Good Health and Well-being

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10.1074/jbc.M114.572560

Cite this

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title = "Unfolded protein response is required for the definitive endodermal specification of mouse embryonic stem cells via Smad2 and βS-catenin signaling",

abstract = "Background: The unfolded protein response (UPR) influences cellular differentiation and function.Results: UPR-inducing agents enhance the differentiation of definitive endoderm cells from mouse ESCs. Inhibition of the UPR prevents the specific differentiation.Conclusion: The UPR is required for the formation of definitive endoderm cells.Significance: This study identifies a new molecular mechanism that interconnects the UPR and cell fate decisions in early embryonic development.",

author = "Huiming Xu and Tsang, \{Kam Sze\} and Yonghui Wang and Chan, \{Juliana C.N.\} and Gang Xu and Gao, \{Wei Qiang\}",

note = "This work was supported by grants from the National Basic Research Program of China (2012CB967903, 2012CB966800, and 2013CB945600), National Natural Science Foundation of China (81270438, 81130038, and 81372189), Science and Technology Commission of Shanghai Municipality (Pujiang program), Shanghai Health Bureau Key Discipline and Specialty Foundation (J50208), Shanghai Education Committee Key Discipline and Specialty Foundation, and KC Wong Foundation. ",

year = "2014",

month = sep,

day = "19",

doi = "10.1074/jbc.M114.572560",

language = "English",

volume = "289",

pages = "26290--26301",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

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TY - JOUR

T1 - Unfolded protein response is required for the definitive endodermal specification of mouse embryonic stem cells via Smad2 and βS-catenin signaling

AU - Xu, Huiming

AU - Tsang, Kam Sze

AU - Wang, Yonghui

AU - Chan, Juliana C.N.

AU - Xu, Gang

AU - Gao, Wei Qiang

N1 - This work was supported by grants from the National Basic Research Program of China (2012CB967903, 2012CB966800, and 2013CB945600), National Natural Science Foundation of China (81270438, 81130038, and 81372189), Science and Technology Commission of Shanghai Municipality (Pujiang program), Shanghai Health Bureau Key Discipline and Specialty Foundation (J50208), Shanghai Education Committee Key Discipline and Specialty Foundation, and KC Wong Foundation.

PY - 2014/9/19

Y1 - 2014/9/19

N2 - Background: The unfolded protein response (UPR) influences cellular differentiation and function.Results: UPR-inducing agents enhance the differentiation of definitive endoderm cells from mouse ESCs. Inhibition of the UPR prevents the specific differentiation.Conclusion: The UPR is required for the formation of definitive endoderm cells.Significance: This study identifies a new molecular mechanism that interconnects the UPR and cell fate decisions in early embryonic development.

AB - Background: The unfolded protein response (UPR) influences cellular differentiation and function.Results: UPR-inducing agents enhance the differentiation of definitive endoderm cells from mouse ESCs. Inhibition of the UPR prevents the specific differentiation.Conclusion: The UPR is required for the formation of definitive endoderm cells.Significance: This study identifies a new molecular mechanism that interconnects the UPR and cell fate decisions in early embryonic development.

UR - https://www.scopus.com/pages/publications/84907223749

U2 - 10.1074/jbc.M114.572560

DO - 10.1074/jbc.M114.572560

M3 - Journal article

C2 - 25092289

AN - SCOPUS:84907223749

SN - 0021-9258

VL - 289

SP - 26290

EP - 26301

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 38

ER -

Unfolded protein response is required for the definitive endodermal specification of mouse embryonic stem cells via Smad2 and βS-catenin signaling

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