Unfolded protein response is required for the definitive endodermal specification of mouse embryonic stem cells via Smad2 and βS-catenin signaling

Huiming Xu; Kam Sze Tsang; Yonghui Wang; Juliana C.N. Chan; Gang XU; Wei Qiang Gao

doi:10.1074/jbc.M114.572560

Unfolded protein response is required for the definitive endodermal specification of mouse embryonic stem cells via Smad2 and βS-catenin signaling

Huiming Xu, Kam Sze Tsang, Yonghui Wang, Juliana C.N. Chan, Gang XU^*, Wei Qiang Gao

^*Corresponding author for this work

School of Chinese Medicine

Research output: Contribution to journal › Journal article › peer-review

26 Citations (Scopus)

Abstract

Background: The unfolded protein response (UPR) influences cellular differentiation and function.

Results: UPR-inducing agents enhance the differentiation of definitive endoderm cells from mouse ESCs. Inhibition of the UPR prevents the specific differentiation.

Conclusion: The UPR is required for the formation of definitive endoderm cells.

Significance: This study identifies a new molecular mechanism that interconnects the UPR and cell fate decisions in early embryonic development.

Original language	English
Pages (from-to)	26290-26301
Number of pages	12
Journal	Journal of Biological Chemistry
Volume	289
Issue number	38
DOIs	https://doi.org/10.1074/jbc.M114.572560
Publication status	Published - 19 Sept 2014

Scopus Subject Areas

Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1074/jbc.M114.572560

Cite this

@article{eac63dc834bf4f11afde5dc24c8a7e4a,

title = "Unfolded protein response is required for the definitive endodermal specification of mouse embryonic stem cells via Smad2 and βS-catenin signaling",

abstract = "Background: The unfolded protein response (UPR) influences cellular differentiation and function.Results: UPR-inducing agents enhance the differentiation of definitive endoderm cells from mouse ESCs. Inhibition of the UPR prevents the specific differentiation.Conclusion: The UPR is required for the formation of definitive endoderm cells.Significance: This study identifies a new molecular mechanism that interconnects the UPR and cell fate decisions in early embryonic development.",

author = "Huiming Xu and Tsang, {Kam Sze} and Yonghui Wang and Chan, {Juliana C.N.} and Gang XU and Gao, {Wei Qiang}",

year = "2014",

month = sep,

day = "19",

doi = "10.1074/jbc.M114.572560",

language = "English",

volume = "289",

pages = "26290--26301",

journal = "Journal of Biological Chemistry",

issn = "0021-9258",

publisher = "American Society for Biochemistry and Molecular Biology Inc.; Elsevier",

number = "38",

}

TY - JOUR

T1 - Unfolded protein response is required for the definitive endodermal specification of mouse embryonic stem cells via Smad2 and βS-catenin signaling

AU - Xu, Huiming

AU - Tsang, Kam Sze

AU - Wang, Yonghui

AU - Chan, Juliana C.N.

AU - XU, Gang

AU - Gao, Wei Qiang

PY - 2014/9/19

Y1 - 2014/9/19

N2 - Background: The unfolded protein response (UPR) influences cellular differentiation and function.Results: UPR-inducing agents enhance the differentiation of definitive endoderm cells from mouse ESCs. Inhibition of the UPR prevents the specific differentiation.Conclusion: The UPR is required for the formation of definitive endoderm cells.Significance: This study identifies a new molecular mechanism that interconnects the UPR and cell fate decisions in early embryonic development.

AB - Background: The unfolded protein response (UPR) influences cellular differentiation and function.Results: UPR-inducing agents enhance the differentiation of definitive endoderm cells from mouse ESCs. Inhibition of the UPR prevents the specific differentiation.Conclusion: The UPR is required for the formation of definitive endoderm cells.Significance: This study identifies a new molecular mechanism that interconnects the UPR and cell fate decisions in early embryonic development.

UR - http://www.scopus.com/inward/record.url?scp=84907223749&partnerID=8YFLogxK

U2 - 10.1074/jbc.M114.572560

DO - 10.1074/jbc.M114.572560

M3 - Journal article

C2 - 25092289

AN - SCOPUS:84907223749

SN - 0021-9258

VL - 289

SP - 26290

EP - 26301

JO - Journal of Biological Chemistry

JF - Journal of Biological Chemistry

IS - 38

ER -

Unfolded protein response is required for the definitive endodermal specification of mouse embryonic stem cells via Smad2 and βS-catenin signaling

Abstract

Scopus Subject Areas

Access to Document

Other files and links

Fingerprint

Cite this