Background: The unfolded protein response (UPR) influences cellular differentiation and function.
Results: UPR-inducing agents enhance the differentiation of definitive endoderm cells from mouse ESCs. Inhibition of the UPR prevents the specific differentiation.
Conclusion: The UPR is required for the formation of definitive endoderm cells.
Significance: This study identifies a new molecular mechanism that interconnects the UPR and cell fate decisions in early embryonic development.
Scopus Subject Areas
- Molecular Biology
- Cell Biology