Unfolded protein response is required for the definitive endodermal specification of mouse embryonic stem cells via Smad2 and βS-catenin signaling

Huiming Xu, Kam Sze Tsang, Yonghui Wang, Juliana C.N. Chan, Gang XU*, Wei Qiang Gao

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Background: The unfolded protein response (UPR) influences cellular differentiation and function.

Results: UPR-inducing agents enhance the differentiation of definitive endoderm cells from mouse ESCs. Inhibition of the UPR prevents the specific differentiation.

Conclusion: The UPR is required for the formation of definitive endoderm cells.

Significance: This study identifies a new molecular mechanism that interconnects the UPR and cell fate decisions in early embryonic development.

Original languageEnglish
Pages (from-to)26290-26301
Number of pages12
JournalJournal of Biological Chemistry
Volume289
Issue number38
DOIs
Publication statusPublished - 19 Sep 2014

Scopus Subject Areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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