@article{eac63dc834bf4f11afde5dc24c8a7e4a,
title = "Unfolded protein response is required for the definitive endodermal specification of mouse embryonic stem cells via Smad2 and βS-catenin signaling",
abstract = "Background: The unfolded protein response (UPR) influences cellular differentiation and function.Results: UPR-inducing agents enhance the differentiation of definitive endoderm cells from mouse ESCs. Inhibition of the UPR prevents the specific differentiation.Conclusion: The UPR is required for the formation of definitive endoderm cells.Significance: This study identifies a new molecular mechanism that interconnects the UPR and cell fate decisions in early embryonic development.",
author = "Huiming Xu and Tsang, {Kam Sze} and Yonghui Wang and Chan, {Juliana C.N.} and Gang Xu and Gao, {Wei Qiang}",
note = "This work was supported by grants from the National Basic Research Program of China (2012CB967903, 2012CB966800, and 2013CB945600), National Natural Science Foundation of China (81270438, 81130038, and 81372189), Science and Technology Commission of Shanghai Municipality (Pujiang program), Shanghai Health Bureau Key Discipline and Specialty Foundation (J50208), Shanghai Education Committee Key Discipline and Specialty Foundation, and KC Wong Foundation. ",
year = "2014",
month = sep,
day = "19",
doi = "10.1074/jbc.M114.572560",
language = "English",
volume = "289",
pages = "26290--26301",
journal = "Journal of Biological Chemistry",
issn = "0021-9258",
publisher = "American Society for Biochemistry and Molecular Biology Inc.; Elsevier",
number = "38",
}
