Abstract
Background: The unfolded protein response (UPR) influences cellular differentiation and function.
Results: UPR-inducing agents enhance the differentiation of definitive endoderm cells from mouse ESCs. Inhibition of the UPR prevents the specific differentiation.
Conclusion: The UPR is required for the formation of definitive endoderm cells.
Significance: This study identifies a new molecular mechanism that interconnects the UPR and cell fate decisions in early embryonic development.
Original language | English |
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Pages (from-to) | 26290-26301 |
Number of pages | 12 |
Journal | Journal of Biological Chemistry |
Volume | 289 |
Issue number | 38 |
DOIs | |
Publication status | Published - 19 Sept 2014 |
Scopus Subject Areas
- Biochemistry
- Molecular Biology
- Cell Biology