TY - GEN
T1 - Understanding synergetic activities of Fuzi-Dahuang herb pairs based on network pharmacology
AU - Tan, Yong
AU - Lu, Cheng
AU - Jiang, Miao
AU - Li, Li
AU - He, Xiaojuan
AU - Han, Xuejie
AU - LYU, Aiping
AU - Li, Jian
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2013
Y1 - 2013
N2 - Objectives: In order to better understand the synergetic activities of radix aconite lateralis praeparata (Fuzi)-rheum officinale (Dahuang) herb pairs. Material and methods: The target proteins of Fuzi and Dahuang were retrieved from PubChem database and were uploaded to ingenuity pathway analysis (IPA) platform. Then we carried out molecular network analysis and canonical pathway analysis. Finally, we found out specific molecules, networks and pathways, which embodied the synergetic activities of Fuzi-Dahuang herb pairs. Results: 5 target proteins in Fuzi and 44 target proteins in Dahuang were retrieved from PubChem database. Ubiquitin C (UBC) is a shared molecule in Fuzi network and Dahuang network. Bio-functions of Fuzi and Dahuang involved in gastrointestinal disease, cardiovascular disease, endocrine system disorders, inflammatory disease, as well as renal and urological disease, etc. 14-3-3 mediated signaling is the pathway related with tubulin and tau that are from Fuzi and Dahuang target proteins respectively. Conclusions: Regulating UBC and 14-3-3 mediated signaling pathway might partly decipher the synergetic biological activities of Fuzi-Dahuang herb pairs. Network pharmacology approaches contribute to find the biological activities of herb pairs fully. This study provides a new paradigm for better understanding the synergy mechanism of the compatibility of herb pairs.
AB - Objectives: In order to better understand the synergetic activities of radix aconite lateralis praeparata (Fuzi)-rheum officinale (Dahuang) herb pairs. Material and methods: The target proteins of Fuzi and Dahuang were retrieved from PubChem database and were uploaded to ingenuity pathway analysis (IPA) platform. Then we carried out molecular network analysis and canonical pathway analysis. Finally, we found out specific molecules, networks and pathways, which embodied the synergetic activities of Fuzi-Dahuang herb pairs. Results: 5 target proteins in Fuzi and 44 target proteins in Dahuang were retrieved from PubChem database. Ubiquitin C (UBC) is a shared molecule in Fuzi network and Dahuang network. Bio-functions of Fuzi and Dahuang involved in gastrointestinal disease, cardiovascular disease, endocrine system disorders, inflammatory disease, as well as renal and urological disease, etc. 14-3-3 mediated signaling is the pathway related with tubulin and tau that are from Fuzi and Dahuang target proteins respectively. Conclusions: Regulating UBC and 14-3-3 mediated signaling pathway might partly decipher the synergetic biological activities of Fuzi-Dahuang herb pairs. Network pharmacology approaches contribute to find the biological activities of herb pairs fully. This study provides a new paradigm for better understanding the synergy mechanism of the compatibility of herb pairs.
KW - network pharmacology
KW - radix aconite lateralis praeparata (Fuzi)
KW - rheum officinale (Dahuang)
KW - synergetic activities
UR - http://www.scopus.com/inward/record.url?scp=84894570532&partnerID=8YFLogxK
U2 - 10.1109/BIBM.2013.6732604
DO - 10.1109/BIBM.2013.6732604
M3 - Conference proceeding
AN - SCOPUS:84894570532
SN - 9781479913091
T3 - Proceedings - 2013 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2013
SP - 16
EP - 21
BT - Proceedings - 2013 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2013
T2 - 2013 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2013
Y2 - 18 December 2013 through 21 December 2013
ER -
