TY - JOUR
T1 - Understanding structural-functional relationships in the human brain
T2 - A large-scale network perspective
AU - Wang, Zhijiang
AU - Dai, Zhengjia
AU - Gong, Gaolang
AU - ZHOU, Changsong
AU - He, Yong
N1 - Funding Information:
The author(s) disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: This work was supported by the National Key Basic Research Program of China (Grant Nos. 2013CB837300 and 2014CB846102), the National Science Fund for Distinguished Young Scholars (Grant No. 81225012), the Natural Science Foundation of China (Grant Nos. 81030028, 11328501, 11275027 and 81322021), the Beijing Funding for Training Talents (YH), the Beijing Nova Program (Grant No Z121110002512032), the CERS–China Equipment and Education Resources System (CERS-1-52), and the Fundamental Research Funds for the Central Universities (2012CXQT01).
PY - 2015/6/4
Y1 - 2015/6/4
N2 - Relating the brain's structural connectivity (SC) to its functional connectivity (FC) is a fundamental goal in neuroscience because it is capable of aiding our understanding of how the relatively fixed SC architecture underlies human cognition and diverse behaviors. With the aid of current noninvasive imaging technologies (e.g., structural MRI, diffusion MRI, and functional MRI) and graph theory methods, researchers have modeled the human brain as a complex network of interacting neuronal elements and characterized the underlying structural and functional connectivity patterns that support diverse cognitive functions. Specifically, research has demonstrated a tight SC-FC coupling, not only in interregional connectivity strength but also in network topologic organizations, such as community, rich-club, and motifs. Moreover, this SC-FC coupling exhibits significant changes in normal development and neuropsychiatric disorders, such as schizophrenia and epilepsy. This review summarizes recent progress regarding the SC-FC relationship of the human brain and emphasizes the important role of large-scale brain networks in the understanding of structural-functional associations. Future research directions related to this topic are also proposed.
AB - Relating the brain's structural connectivity (SC) to its functional connectivity (FC) is a fundamental goal in neuroscience because it is capable of aiding our understanding of how the relatively fixed SC architecture underlies human cognition and diverse behaviors. With the aid of current noninvasive imaging technologies (e.g., structural MRI, diffusion MRI, and functional MRI) and graph theory methods, researchers have modeled the human brain as a complex network of interacting neuronal elements and characterized the underlying structural and functional connectivity patterns that support diverse cognitive functions. Specifically, research has demonstrated a tight SC-FC coupling, not only in interregional connectivity strength but also in network topologic organizations, such as community, rich-club, and motifs. Moreover, this SC-FC coupling exhibits significant changes in normal development and neuropsychiatric disorders, such as schizophrenia and epilepsy. This review summarizes recent progress regarding the SC-FC relationship of the human brain and emphasizes the important role of large-scale brain networks in the understanding of structural-functional associations. Future research directions related to this topic are also proposed.
KW - connectome
KW - functional connectivity
KW - graph theory
KW - module
KW - rich club
KW - structural connectivity
UR - http://www.scopus.com/inward/record.url?scp=84930358524&partnerID=8YFLogxK
U2 - 10.1177/1073858414537560
DO - 10.1177/1073858414537560
M3 - Review article
C2 - 24962094
AN - SCOPUS:84930358524
SN - 1073-8584
VL - 21
SP - 290
EP - 305
JO - Neuroscientist
JF - Neuroscientist
IS - 3
ER -