TY - JOUR
T1 - Uncovering the Anticancer Mechanisms of Chinese Herbal Medicine Formulas
T2 - Therapeutic Alternatives for Liver Cancer
AU - Chen, Feiyu
AU - Zhong, Zhangfeng
AU - Tan, Hor Yue
AU - Guo, Wei
AU - Zhang, Cheng
AU - Tan, Chi Wing
AU - Li, Sha
AU - Wang, Ning
AU - Feng, Yibin
N1 - Funding information:
This research was partially supported by the Research Council of the University of Hong Kong (project codes: 104004092 and 104004460), Wong's donation (project code: 200006276), a donation from the Gaia Family Trust of New Zealand (project code: 200007008), the Research Grants Committee (RGC) of Hong Kong, HKSAR (Project Codes: 740608, 766211, 17152116 and 17121419) and Health and Medical Research Fund (Project code: 16172751).
Publisher Copyright:
© 2020 Chen, Zhong, Tan, Guo, Zhang, Tan, Li, Wang and Feng.
PY - 2020/3/18
Y1 - 2020/3/18
N2 - The potential values of Chinese herbal formulas in treating various diseases are well known. In addition to more than 2,000 years of history, herbal medicine is appreciated for its remarkable efficacy in a lot of cases, which warrants a role in public health care worldwide, especially in East Asian countries. Liver cancer is the second most fatal cancer across the world. Recent studies have extensively investigated the chemical profiles and pharmacological effects of Chinese herbal medicine formulas on liver cancer. Either through observational follow-up or experimental studies, multiple herbal formulas have benefits implicated in the management of liver cancer. However, complex composition of each formula imposes restrictions on promoting clinical practice and global recognition. Therefore, understanding the mode of action of Chinese herbal medicine formulas in depth may offer sufficient evidence for their clinical use. This review highlighted the chemical characteristics and molecular mechanisms of actions of prominent Chinese herbal medicine formulas and summarized the correlated findings on the potential use in liver cancer treatment. At last, the present progresses of Chinese herbal medicine formulas in the perspective of clinical trials are discussed.
AB - The potential values of Chinese herbal formulas in treating various diseases are well known. In addition to more than 2,000 years of history, herbal medicine is appreciated for its remarkable efficacy in a lot of cases, which warrants a role in public health care worldwide, especially in East Asian countries. Liver cancer is the second most fatal cancer across the world. Recent studies have extensively investigated the chemical profiles and pharmacological effects of Chinese herbal medicine formulas on liver cancer. Either through observational follow-up or experimental studies, multiple herbal formulas have benefits implicated in the management of liver cancer. However, complex composition of each formula imposes restrictions on promoting clinical practice and global recognition. Therefore, understanding the mode of action of Chinese herbal medicine formulas in depth may offer sufficient evidence for their clinical use. This review highlighted the chemical characteristics and molecular mechanisms of actions of prominent Chinese herbal medicine formulas and summarized the correlated findings on the potential use in liver cancer treatment. At last, the present progresses of Chinese herbal medicine formulas in the perspective of clinical trials are discussed.
KW - alternative therapy
KW - cancer
KW - Chinese herbal medicine formula
KW - hepatocellular carcinoma
KW - liver cancer
UR - http://www.scopus.com/inward/record.url?scp=85082689196&partnerID=8YFLogxK
U2 - 10.3389/fphar.2020.00293
DO - 10.3389/fphar.2020.00293
M3 - Review article
AN - SCOPUS:85082689196
SN - 1663-9812
VL - 11
JO - Frontiers in Pharmacology
JF - Frontiers in Pharmacology
M1 - 293
ER -
