Ultrasound, pH, and magnetically responsive crown-ether-coated core/shell nanoparticles as drug encapsulation and release systems

Siu Fung Lee, Xiao Ming Zhu, Yi Xiang J. Wang, Shou Hu Xuan, Qihua You, Wing Hong CHAN, Chi Hin Wong, Feng Wang, Jimmy C. Yu, Christopher H.K. Cheng, Ken C F LEUNG*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

102 Citations (Scopus)

Abstract

Core@shell nanoparticles with superparamagnetic iron oxide core, mesoporous silica shell, and crown ether periphery were fabricated toward drug delivery and tumor cell imaging. By the concept of nanovalve based on supramolecular gatekeeper, stimuli-responsive drug delivery nanosystems Fe3O 4@SiO2@meso-SiO2@crown ethers were synthesized by (i) modified solvothermal reaction; (ii) sol-gel reaction; and (iii) amide coupling reaction. The successful coupling of the dibenzo-crown ethers onto the mesoporous silica shell was confirmed by thermogravimetric analysis and Infrared spectroscopy. In this system, the "ON/OFF" switching of the gatekeeper supramolecules can be controlled by pH-sensitive intramolecular hydrogen bonding or electrostatic interaction (such as metal chelating). Biological evaluation of the nanoparticles renders them noncytotoxic and can be uptaken by L929 cells. In this work, the antitumor drug (doxorubicin) loading and release profiles which were studied by the UV/visible absorption spectroscopy. The mechanism involves the best-fit binding of crown ethers with cesium or sodium ions at different pH values with ultrasonic wave in phosphate buffered saline (PBS). Magnetic resonance imaging analysis of the particles reveals a high relaxivity, rendering them potentially useful theranostic agents.

Original languageEnglish
Pages (from-to)1566-1574
Number of pages9
JournalACS applied materials & interfaces
Volume5
Issue number5
DOIs
Publication statusPublished - 13 Mar 2013

Scopus Subject Areas

  • Materials Science(all)

User-Defined Keywords

  • crown ether
  • drug carrier
  • magnetic resonance imaging
  • nanoparticle
  • ultrasound

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