UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, catalyzes the regiospecific glycosylation of pentacyclic triterpenoids

Junbin He; Kuan Chen; Zhi min Hu; Kai Li; Wei Song; Li yan Yu; Chung Hang Leung; Dik Lung Ma; Xue Qiao; Min Ye

doi:10.1039/c8cc04215b

UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, catalyzes the regiospecific glycosylation of pentacyclic triterpenoids

Junbin He
, Kuan Chen
, Zhi min Hu
, Kai Li
, Wei Song
, Li yan Yu
, Chung Hang Leung
, Dik Lung Ma
, Xue Qiao^*
, Min Ye

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

44 Citations (Scopus)

Abstract

The regiospecific glycosylation of pentacyclic triterpenoids by UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, is highlighted. UGT73F17 exhibited strict substrate specificity toward the carboxyl group at C-30/C-29 of pentacyclic triterpenoids, and showed high promiscuity to sugar donors. UGT73F17 represents the first identified triterpenoid 30/29-O-glycosyltransferase, and could be used as an effective biocatalyst to synthesize glycosyl ester saponins.

Original language	English
Pages (from-to)	8594-8597
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	62
DOIs	https://doi.org/10.1039/c8cc04215b
Publication status	Published - 2018

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title = "UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, catalyzes the regiospecific glycosylation of pentacyclic triterpenoids",

abstract = "The regiospecific glycosylation of pentacyclic triterpenoids by UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, is highlighted. UGT73F17 exhibited strict substrate specificity toward the carboxyl group at C-30/C-29 of pentacyclic triterpenoids, and showed high promiscuity to sugar donors. UGT73F17 represents the first identified triterpenoid 30/29-O-glycosyltransferase, and could be used as an effective biocatalyst to synthesize glycosyl ester saponins.",

author = "Junbin He and Kuan Chen and Hu, \{Zhi min\} and Kai Li and Wei Song and Yu, \{Li yan\} and Leung, \{Chung Hang\} and Ma, \{Dik Lung\} and Xue Qiao and Min Ye",

note = "Funding Information: This work was supported by National Natural Science Foundation of China (No. 81725023) and Young Elite Scientists Sponsorship Program by China Association for Science and Technology (2016QNRC001).",

year = "2018",

doi = "10.1039/c8cc04215b",

language = "English",

volume = "54",

pages = "8594--8597",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "62",

}

TY - JOUR

T1 - UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, catalyzes the regiospecific glycosylation of pentacyclic triterpenoids

AU - He, Junbin

AU - Chen, Kuan

AU - Hu, Zhi min

AU - Li, Kai

AU - Song, Wei

AU - Yu, Li yan

AU - Leung, Chung Hang

AU - Ma, Dik Lung

AU - Qiao, Xue

AU - Ye, Min

N1 - Funding Information: This work was supported by National Natural Science Foundation of China (No. 81725023) and Young Elite Scientists Sponsorship Program by China Association for Science and Technology (2016QNRC001).

PY - 2018

Y1 - 2018

N2 - The regiospecific glycosylation of pentacyclic triterpenoids by UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, is highlighted. UGT73F17 exhibited strict substrate specificity toward the carboxyl group at C-30/C-29 of pentacyclic triterpenoids, and showed high promiscuity to sugar donors. UGT73F17 represents the first identified triterpenoid 30/29-O-glycosyltransferase, and could be used as an effective biocatalyst to synthesize glycosyl ester saponins.

AB - The regiospecific glycosylation of pentacyclic triterpenoids by UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, is highlighted. UGT73F17 exhibited strict substrate specificity toward the carboxyl group at C-30/C-29 of pentacyclic triterpenoids, and showed high promiscuity to sugar donors. UGT73F17 represents the first identified triterpenoid 30/29-O-glycosyltransferase, and could be used as an effective biocatalyst to synthesize glycosyl ester saponins.

UR - https://www.scopus.com/pages/publications/85050887413

U2 - 10.1039/c8cc04215b

DO - 10.1039/c8cc04215b

M3 - Journal article

C2 - 30010690

AN - SCOPUS:85050887413

SN - 1359-7345

VL - 54

SP - 8594

EP - 8597

JO - Chemical Communications

JF - Chemical Communications

IS - 62

ER -

UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, catalyzes the regiospecific glycosylation of pentacyclic triterpenoids

Abstract

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