UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, catalyzes the regiospecific glycosylation of pentacyclic triterpenoids

Junbin He; Kuan Chen; Zhi min Hu; Kai Li; Wei Song; Li yan Yu; Chung Hang Leung; Dik Lung Ma; Xue Qiao; Min Ye

doi:10.1039/c8cc04215b

UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, catalyzes the regiospecific glycosylation of pentacyclic triterpenoids

Junbin He, Kuan Chen, Zhi min Hu, Kai Li, Wei Song, Li yan Yu, Chung Hang Leung, Dik Lung Ma, Xue Qiao^*, Min Ye

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Journal article › peer-review

43 Citations (Scopus)

Abstract

The regiospecific glycosylation of pentacyclic triterpenoids by UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, is highlighted. UGT73F17 exhibited strict substrate specificity toward the carboxyl group at C-30/C-29 of pentacyclic triterpenoids, and showed high promiscuity to sugar donors. UGT73F17 represents the first identified triterpenoid 30/29-O-glycosyltransferase, and could be used as an effective biocatalyst to synthesize glycosyl ester saponins.

Original language	English
Pages (from-to)	8594-8597
Number of pages	4
Journal	Chemical Communications
Volume	54
Issue number	62
DOIs	https://doi.org/10.1039/c8cc04215b
Publication status	Published - 2018

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title = "UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, catalyzes the regiospecific glycosylation of pentacyclic triterpenoids",

abstract = "The regiospecific glycosylation of pentacyclic triterpenoids by UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, is highlighted. UGT73F17 exhibited strict substrate specificity toward the carboxyl group at C-30/C-29 of pentacyclic triterpenoids, and showed high promiscuity to sugar donors. UGT73F17 represents the first identified triterpenoid 30/29-O-glycosyltransferase, and could be used as an effective biocatalyst to synthesize glycosyl ester saponins.",

author = "Junbin He and Kuan Chen and Hu, {Zhi min} and Kai Li and Wei Song and Yu, {Li yan} and Leung, {Chung Hang} and Ma, {Dik Lung} and Xue Qiao and Min Ye",

note = "Funding Information: This work was supported by National Natural Science Foundation of China (No. 81725023) and Young Elite Scientists Sponsorship Program by China Association for Science and Technology (2016QNRC001).",

year = "2018",

doi = "10.1039/c8cc04215b",

language = "English",

volume = "54",

pages = "8594--8597",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

number = "62",

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TY - JOUR

T1 - UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, catalyzes the regiospecific glycosylation of pentacyclic triterpenoids

AU - He, Junbin

AU - Chen, Kuan

AU - Hu, Zhi min

AU - Li, Kai

AU - Song, Wei

AU - Yu, Li yan

AU - Leung, Chung Hang

AU - Ma, Dik Lung

AU - Qiao, Xue

AU - Ye, Min

N1 - Funding Information: This work was supported by National Natural Science Foundation of China (No. 81725023) and Young Elite Scientists Sponsorship Program by China Association for Science and Technology (2016QNRC001).

PY - 2018

Y1 - 2018

N2 - The regiospecific glycosylation of pentacyclic triterpenoids by UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, is highlighted. UGT73F17 exhibited strict substrate specificity toward the carboxyl group at C-30/C-29 of pentacyclic triterpenoids, and showed high promiscuity to sugar donors. UGT73F17 represents the first identified triterpenoid 30/29-O-glycosyltransferase, and could be used as an effective biocatalyst to synthesize glycosyl ester saponins.

AB - The regiospecific glycosylation of pentacyclic triterpenoids by UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, is highlighted. UGT73F17 exhibited strict substrate specificity toward the carboxyl group at C-30/C-29 of pentacyclic triterpenoids, and showed high promiscuity to sugar donors. UGT73F17 represents the first identified triterpenoid 30/29-O-glycosyltransferase, and could be used as an effective biocatalyst to synthesize glycosyl ester saponins.

UR - http://www.scopus.com/inward/record.url?scp=85050887413&partnerID=8YFLogxK

U2 - 10.1039/c8cc04215b

DO - 10.1039/c8cc04215b

M3 - Journal article

C2 - 30010690

AN - SCOPUS:85050887413

SN - 1359-7345

VL - 54

SP - 8594

EP - 8597

JO - Chemical Communications

JF - Chemical Communications

IS - 62

ER -

UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, catalyzes the regiospecific glycosylation of pentacyclic triterpenoids

Abstract

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