UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, catalyzes the regiospecific glycosylation of pentacyclic triterpenoids

Junbin He, Kuan Chen, Zhi min Hu, Kai Li, Wei Song, Li yan Yu, Chung Hang Leung, Dik Lung Ma, Xue Qiao*, Min Ye

*Corresponding author for this work

Research output: Contribution to journalJournal articlepeer-review

43 Citations (Scopus)

Abstract

The regiospecific glycosylation of pentacyclic triterpenoids by UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, is highlighted. UGT73F17 exhibited strict substrate specificity toward the carboxyl group at C-30/C-29 of pentacyclic triterpenoids, and showed high promiscuity to sugar donors. UGT73F17 represents the first identified triterpenoid 30/29-O-glycosyltransferase, and could be used as an effective biocatalyst to synthesize glycosyl ester saponins.

Original languageEnglish
Pages (from-to)8594-8597
Number of pages4
JournalChemical Communications
Volume54
Issue number62
DOIs
Publication statusPublished - 2018

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