Ubiquitination Regulators Discovered by Virtual Screening for the Treatment of Cancer

Ying Qi Song, Chun Wu, Ke Jia Wu, Quan Bin Han, Xiang Min Miao, Dik Lung Ma, Chung Hang Leung*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

The ubiquitin-proteasome system oversees cellular protein degradation in order to regulate various critical processes, such as cell cycle control and DNA repair. Ubiquitination can serve as a marker for mutation, chemical damage, transcriptional or translational errors, and heat-induced denaturation. However, aberrant ubiquitination and degradation of tumor suppressor proteins may result in the growth and metastasis of cancer. Hence, targeting the ubiquitination cascade reaction has become a potential strategy for treating malignant diseases. Meanwhile, computer-aided methods have become widely accepted as fast and efficient techniques for early stage drug discovery. This review summarizes ubiquitination regulators that have been discovered via virtual screening and their applications for cancer treatment.

Original languageEnglish
Article number665646
JournalFrontiers in Cell and Developmental Biology
Volume9
DOIs
Publication statusPublished - 12 May 2021

Scopus Subject Areas

  • Developmental Biology
  • Cell Biology

User-Defined Keywords

  • cancer
  • drug discovery
  • treatment
  • ubiquitination regulator
  • virtual screening

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