Type III-C rotaxane dendrimers: synthesis, dual size modulation and in vivo evaluation

Chak Shing Kwan; Tao Wang; Min Li; Albert S. C. Chan; Zongwei Cai; Ken Cham Fai Leung

doi:10.1039/c9cc06200a

Type III-C rotaxane dendrimers: synthesis, dual size modulation and in vivo evaluation

Chak Shing Kwan, Tao Wang, Min Li, Albert S. C. Chan, Zongwei Cai^*, Ken Cham Fai Leung^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

Abstract

Type III-C rotaxane dendrimers were synthesized by a divergent approach. Dual shuttling behavior and size modulation were observed from non-methylated/methylated rotaxane dendrimers under the same external stimuli. The biological distribution of dendrimers in C57BL/6J mice determined by MALDI-TOF-MS shows predominant accumulation in the spleen and liver. Drug encapsulations with chlorambucil and lithocholic acid were demonstrated.

Original language	English
Pages (from-to)	13426-13429
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	89
Early online date	14 Oct 2019
DOIs	https://doi.org/10.1039/c9cc06200a
Publication status	Published - 18 Nov 2019

Scopus Subject Areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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title = "Type III-C rotaxane dendrimers: synthesis, dual size modulation and in vivo evaluation",

abstract = "Type III-C rotaxane dendrimers were synthesized by a divergent approach. Dual shuttling behavior and size modulation were observed from non-methylated/methylated rotaxane dendrimers under the same external stimuli. The biological distribution of dendrimers in C57BL/6J mice determined by MALDI-TOF-MS shows predominant accumulation in the spleen and liver. Drug encapsulations with chlorambucil and lithocholic acid were demonstrated.",

author = "Kwan, {Chak Shing} and Tao Wang and Min Li and Chan, {Albert S. C.} and Zongwei Cai and Leung, {Ken Cham Fai}",

note = "Funding information: We acknowledge the financial support from The State Key Laboratory of Environmental and Biological Analysis, The Interdisciplinary Research Clusters (IRCS/17-18/03) and The President's Award for Outstanding Performance in Research Supervision to K. C.-F. L. from The Hong Kong Baptist University. We also acknowledge Mr David T.-W. Chik for the helpful discussion on the MALDI experiment. We acknowledge the discussions with Professor Sir Fraser Stoddart. Publisher copyright: {\textcopyright} The Royal Society of Chemistry 2019",

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doi = "10.1039/c9cc06200a",

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journal = "Chemical Communications",

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T1 - Type III-C rotaxane dendrimers

T2 - synthesis, dual size modulation and in vivo evaluation

AU - Kwan, Chak Shing

AU - Wang, Tao

AU - Li, Min

AU - Chan, Albert S. C.

AU - Cai, Zongwei

AU - Leung, Ken Cham Fai

N1 - Funding information: We acknowledge the financial support from The State Key Laboratory of Environmental and Biological Analysis, The Interdisciplinary Research Clusters (IRCS/17-18/03) and The President's Award for Outstanding Performance in Research Supervision to K. C.-F. L. from The Hong Kong Baptist University. We also acknowledge Mr David T.-W. Chik for the helpful discussion on the MALDI experiment. We acknowledge the discussions with Professor Sir Fraser Stoddart. Publisher copyright: © The Royal Society of Chemistry 2019

PY - 2019/11/18

Y1 - 2019/11/18

N2 - Type III-C rotaxane dendrimers were synthesized by a divergent approach. Dual shuttling behavior and size modulation were observed from non-methylated/methylated rotaxane dendrimers under the same external stimuli. The biological distribution of dendrimers in C57BL/6J mice determined by MALDI-TOF-MS shows predominant accumulation in the spleen and liver. Drug encapsulations with chlorambucil and lithocholic acid were demonstrated.

AB - Type III-C rotaxane dendrimers were synthesized by a divergent approach. Dual shuttling behavior and size modulation were observed from non-methylated/methylated rotaxane dendrimers under the same external stimuli. The biological distribution of dendrimers in C57BL/6J mice determined by MALDI-TOF-MS shows predominant accumulation in the spleen and liver. Drug encapsulations with chlorambucil and lithocholic acid were demonstrated.

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EP - 13429

JO - Chemical Communications

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ER -

Type III-C rotaxane dendrimers: synthesis, dual size modulation and in vivo evaluation

Abstract

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