Type III-C rotaxane dendrimers: Synthesis, dual size modulation and: In vivo evaluation

Chak Shing Kwan, Tao Wang, Min LI, Albert S C Chan, Zongwei CAI*, Ken C F LEUNG

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Type III-C rotaxane dendrimers were synthesized by a divergent approach. Dual shuttling behavior and size modulation were observed from non-methylated/methylated rotaxane dendrimers under the same external stimuli. The biological distribution of dendrimers in C57BL/6J mice determined by MALDI-TOF-MS shows predominant accumulation in the spleen and liver. Drug encapsulations with chlorambucil and lithocholic acid were demonstrated.

Original languageEnglish
Pages (from-to)13426-13429
Number of pages4
JournalChemical Communications
Volume55
Issue number89
DOIs
Publication statusPublished - 2019

Scopus Subject Areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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