Two proteins with ribosome-inactivating, cytotoxic and abortifacient activities from seeds of Luffa cylindrica roem (Cucurbitaceae)

T. B. Ng*, Ricky N S WONG, H. W. Yeung

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)

Abstract

Two immunologically distinct glycoproteins, with a molecular weight of 28,000 and 28,5000 respectively, were isolated from seeds of Luffa cylindrica using a procedure that involved acetone precipitation, gel filtration on Sephadex G-75 and ion exchange chromatography on CM-Sepharose CL-6B. The proteins differed in the content of aspartic acid, threonine, proline and alanine but were otherwise similar in amino acid composition. The proteins were capable of inducing mid-term abortion in mice, inhibiting protein synthesis in a cell-free system and suppressing thymidine uptake by human choriocarcinoma cells.

Original languageEnglish
Pages (from-to)197-207
Number of pages11
JournalBiochemistry International
Volume27
Issue number2
Publication statusPublished - 1992

Scopus Subject Areas

  • Biochemistry

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