Two pregnane derivatives and a quinolone alkaloid from Helicteres angustifolia

Guo Cai Wang; Tao Li; Ying Rou Wei; Yan Bo Zhang; Yao Lan Li; Stephen Cho Wing Sze; Wen Cai Ye

doi:10.1016/j.fitote.2012.09.016

Two pregnane derivatives and a quinolone alkaloid from Helicteres angustifolia

Guo Cai Wang
, Tao Li
, Ying Rou Wei
, Yan Bo Zhang
, Yao Lan Li
, Stephen Cho Wing Sze^*
, Wen Cai Ye^*

^*Corresponding author for this work

Golden Meditech Centre for NeuroRegeneration Sciences

Research output: Contribution to journal › Journal article › peer-review

20 Citations (Scopus)

Abstract

Phytochemical investigation of the ethanol extract from roots of Helicteres angustifolia led to the isolation of two new pregnane derivatives, heligenin A–B (1–2), and a new quinolone alkaloid, helicterone A (3), along with thirteen known compounds (4–16). The structures of new compounds were established by analysis of extensive spectroscopic data. The absolute configuration of 1 was determined by application of the modified Mosher's method. All of the isolates were evaluated for their anti-proliferative activities against HT-29 human colon cancer cells and OVCA 429 ovarian cancer cells by MTT assay.

Original language	English
Pages (from-to)	1643-1647
Number of pages	5
Journal	Fitoterapia
Volume	83
Issue number	8
DOIs	https://doi.org/10.1016/j.fitote.2012.09.016
Publication status	Published - Dec 2012

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

User-Defined Keywords

Helicteres angustifolia
Sterculiaceae
Pregnane derivatives
Quinolone alkaloid
Anti-proliferative activity

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10.1016/j.fitote.2012.09.016

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@article{88d45a76a202437cbc770021446dee0a,

title = "Two pregnane derivatives and a quinolone alkaloid from Helicteres angustifolia",

abstract = "Phytochemical investigation of the ethanol extract from roots of Helicteres angustifolia led to the isolation of two new pregnane derivatives, heligenin A–B (1–2), and a new quinolone alkaloid, helicterone A (3), along with thirteen known compounds (4–16). The structures of new compounds were established by analysis of extensive spectroscopic data. The absolute configuration of 1 was determined by application of the modified Mosher's method. All of the isolates were evaluated for their anti-proliferative activities against HT-29 human colon cancer cells and OVCA 429 ovarian cancer cells by MTT assay.",

keywords = "Helicteres angustifolia, Sterculiaceae, Pregnane derivatives, Quinolone alkaloid, Anti-proliferative activity",

author = "Wang, \{Guo Cai\} and Tao Li and Wei, \{Ying Rou\} and Zhang, \{Yan Bo\} and Li, \{Yao Lan\} and Sze, \{Stephen Cho Wing\} and Ye, \{Wen Cai\}",

note = "Funding information: This work was supported by grants from the National Natural Science Foundation (No. 81001374 , 81273390 ), Program for Changjiang Scholars and Innovative Research Team in University ( IRT0965 ) and Research Team Program of Natural Science Foundation of Guangdong Province (No. 8351063201000003 ). Publisher copyright: {\textcopyright} 2012 Elsevier B.V. All rights reserved.",

year = "2012",

month = dec,

doi = "10.1016/j.fitote.2012.09.016",

language = "English",

volume = "83",

pages = "1643--1647",

journal = "Fitoterapia",

issn = "0367-326X",

publisher = "Elsevier B.V.",

number = "8",

}

TY - JOUR

T1 - Two pregnane derivatives and a quinolone alkaloid from Helicteres angustifolia

AU - Wang, Guo Cai

AU - Li, Tao

AU - Wei, Ying Rou

AU - Zhang, Yan Bo

AU - Li, Yao Lan

AU - Sze, Stephen Cho Wing

AU - Ye, Wen Cai

N1 - Funding information: This work was supported by grants from the National Natural Science Foundation (No. 81001374 , 81273390 ), Program for Changjiang Scholars and Innovative Research Team in University ( IRT0965 ) and Research Team Program of Natural Science Foundation of Guangdong Province (No. 8351063201000003 ). Publisher copyright: © 2012 Elsevier B.V. All rights reserved.

PY - 2012/12

Y1 - 2012/12

N2 - Phytochemical investigation of the ethanol extract from roots of Helicteres angustifolia led to the isolation of two new pregnane derivatives, heligenin A–B (1–2), and a new quinolone alkaloid, helicterone A (3), along with thirteen known compounds (4–16). The structures of new compounds were established by analysis of extensive spectroscopic data. The absolute configuration of 1 was determined by application of the modified Mosher's method. All of the isolates were evaluated for their anti-proliferative activities against HT-29 human colon cancer cells and OVCA 429 ovarian cancer cells by MTT assay.

AB - Phytochemical investigation of the ethanol extract from roots of Helicteres angustifolia led to the isolation of two new pregnane derivatives, heligenin A–B (1–2), and a new quinolone alkaloid, helicterone A (3), along with thirteen known compounds (4–16). The structures of new compounds were established by analysis of extensive spectroscopic data. The absolute configuration of 1 was determined by application of the modified Mosher's method. All of the isolates were evaluated for their anti-proliferative activities against HT-29 human colon cancer cells and OVCA 429 ovarian cancer cells by MTT assay.

KW - Helicteres angustifolia

KW - Sterculiaceae

KW - Pregnane derivatives

KW - Quinolone alkaloid

KW - Anti-proliferative activity

UR - https://www.scopus.com/pages/publications/84870824890

U2 - 10.1016/j.fitote.2012.09.016

DO - 10.1016/j.fitote.2012.09.016

M3 - Journal article

SN - 0367-326X

VL - 83

SP - 1643

EP - 1647

JO - Fitoterapia

JF - Fitoterapia

IS - 8

ER -

Two pregnane derivatives and a quinolone alkaloid from Helicteres angustifolia

Abstract

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