Abstract
Phytochemical investigation of the ethanol extract from roots of Helicteres angustifolia led to the isolation of two new pregnane derivatives, heligenin A–B (1–2), and a new quinolone alkaloid, helicterone A (3), along with thirteen known compounds (4–16). The structures of new compounds were established by analysis of extensive spectroscopic data. The absolute configuration of 1 was determined by application of the modified Mosher's method. All of the isolates were evaluated for their anti-proliferative activities against HT-29 human colon cancer cells and OVCA 429 ovarian cancer cells by MTT assay.
Original language | English |
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Pages (from-to) | 1643-1647 |
Number of pages | 5 |
Journal | Fitoterapia |
Volume | 83 |
Issue number | 8 |
DOIs | |
Publication status | Published - Dec 2012 |
User-Defined Keywords
- Helicteres angustifolia
- Sterculiaceae
- Pregnane derivatives
- Quinolone alkaloid
- Anti-proliferative activity