Two pregnane derivatives and a quinolone alkaloid from Helicteres angustifolia

Guo Cai Wang, Tao Li, Ying Rou Wei, Yan Bo Zhang, Yao Lan Li, Stephen Cho Wing Sze*, Wen Cai Ye*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Phytochemical investigation of the ethanol extract from roots of Helicteres angustifolia led to the isolation of two new pregnane derivatives, heligenin A–B (1–2), and a new quinolone alkaloid, helicterone A (3), along with thirteen known compounds (4–16). The structures of new compounds were established by analysis of extensive spectroscopic data. The absolute configuration of 1 was determined by application of the modified Mosher's method. All of the isolates were evaluated for their anti-proliferative activities against HT-29 human colon cancer cells and OVCA 429 ovarian cancer cells by MTT assay.
Original languageEnglish
Pages (from-to)1643-1647
Number of pages5
JournalFitoterapia
Volume83
Issue number8
DOIs
Publication statusPublished - Dec 2012
Externally publishedYes

User-Defined Keywords

  • Helicteres angustifolia
  • Sterculiaceae
  • Pregnane derivatives
  • Quinolone alkaloid
  • Anti-proliferative activity

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