Two new xanthones isolated from the stem bark of Garcinia lancilimba

Nian Yun Yang; Quan Bin Han; Xin Wei Cao; Chun Feng Qiao; Jing Zheng Song; Shi Lin Chen; Da Jian Yang; Hillary Yiu; Hong Xi Xu

doi:10.1248/cpb.55.950

Two new xanthones isolated from the stem bark of Garcinia lancilimba

Nian Yun Yang, Quan Bin Han, Xin Wei Cao, Chun Feng Qiao, Jing Zheng Song, Shi Lin Chen, Da Jian Yang, Hillary Yiu, Hong Xi Xu^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

41 Citations (Scopus)

Abstract

Two new xanthones, 1,5,6-trihydroxy-6′,6′-dimethyl-2H- pyrano(2′,3′:3,4)-2-(3-methylbut-2-enyl)xanthone (1) and 1,6,7-trihydroxy-6′,6′-dimethyl-2H-pyrano(2′,3′:3,2) -4-(3-methylbut-2-enyl)xanthone (2), have been isolated from the stem bark of Garcinia lancilimba (Guttiferae), together with six known xanthones. Their structures were identified on the basis of extensive spectral evidence including detailed 2D NMR and HR-MS data. Two new compounds showed moderate inhibitory effect on human breast cancer MDA-MB-435S cell line.

Original language	English
Pages (from-to)	950-952
Number of pages	3
Journal	Chemical and Pharmaceutical Bulletin
Volume	55
Issue number	6
DOIs	https://doi.org/10.1248/cpb.55.950
Publication status	Published - Jun 2007

Scopus Subject Areas

Chemistry(all)
Drug Discovery

User-Defined Keywords

Cytotoxicity
Garcinia lancilimba
Guttiferae
Xanthone

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1248/cpb.55.950

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@article{a046c182a49043c2a5eb1400d0ec45ff,

title = "Two new xanthones isolated from the stem bark of Garcinia lancilimba",

abstract = "Two new xanthones, 1,5,6-trihydroxy-6′,6′-dimethyl-2H- pyrano(2′,3′:3,4)-2-(3-methylbut-2-enyl)xanthone (1) and 1,6,7-trihydroxy-6′,6′-dimethyl-2H-pyrano(2′,3′:3,2) -4-(3-methylbut-2-enyl)xanthone (2), have been isolated from the stem bark of Garcinia lancilimba (Guttiferae), together with six known xanthones. Their structures were identified on the basis of extensive spectral evidence including detailed 2D NMR and HR-MS data. Two new compounds showed moderate inhibitory effect on human breast cancer MDA-MB-435S cell line.",

keywords = "Cytotoxicity, Garcinia lancilimba, Guttiferae, Xanthone",

author = "Yang, {Nian Yun} and Han, {Quan Bin} and Cao, {Xin Wei} and Qiao, {Chun Feng} and Song, {Jing Zheng} and Chen, {Shi Lin} and Yang, {Da Jian} and Hillary Yiu and Xu, {Hong Xi}",

note = "Funding Information: We acknowledge to all assistants and staff in all endoscopy departments, in functional diagnostic units, and in pathohistological departments where the investigation was performed.",

year = "2007",

month = jun,

doi = "10.1248/cpb.55.950",

language = "English",

volume = "55",

pages = "950--952",

journal = "Chemical and Pharmaceutical Bulletin",

issn = "0009-2363",

publisher = "Pharmaceutical Society of Japan",

number = "6",

}

TY - JOUR

T1 - Two new xanthones isolated from the stem bark of Garcinia lancilimba

AU - Yang, Nian Yun

AU - Han, Quan Bin

AU - Cao, Xin Wei

AU - Qiao, Chun Feng

AU - Song, Jing Zheng

AU - Chen, Shi Lin

AU - Yang, Da Jian

AU - Yiu, Hillary

AU - Xu, Hong Xi

N1 - Funding Information: We acknowledge to all assistants and staff in all endoscopy departments, in functional diagnostic units, and in pathohistological departments where the investigation was performed.

PY - 2007/6

Y1 - 2007/6

N2 - Two new xanthones, 1,5,6-trihydroxy-6′,6′-dimethyl-2H- pyrano(2′,3′:3,4)-2-(3-methylbut-2-enyl)xanthone (1) and 1,6,7-trihydroxy-6′,6′-dimethyl-2H-pyrano(2′,3′:3,2) -4-(3-methylbut-2-enyl)xanthone (2), have been isolated from the stem bark of Garcinia lancilimba (Guttiferae), together with six known xanthones. Their structures were identified on the basis of extensive spectral evidence including detailed 2D NMR and HR-MS data. Two new compounds showed moderate inhibitory effect on human breast cancer MDA-MB-435S cell line.

AB - Two new xanthones, 1,5,6-trihydroxy-6′,6′-dimethyl-2H- pyrano(2′,3′:3,4)-2-(3-methylbut-2-enyl)xanthone (1) and 1,6,7-trihydroxy-6′,6′-dimethyl-2H-pyrano(2′,3′:3,2) -4-(3-methylbut-2-enyl)xanthone (2), have been isolated from the stem bark of Garcinia lancilimba (Guttiferae), together with six known xanthones. Their structures were identified on the basis of extensive spectral evidence including detailed 2D NMR and HR-MS data. Two new compounds showed moderate inhibitory effect on human breast cancer MDA-MB-435S cell line.

KW - Cytotoxicity

KW - Garcinia lancilimba

KW - Guttiferae

KW - Xanthone

UR - http://www.scopus.com/inward/record.url?scp=34250018491&partnerID=8YFLogxK

U2 - 10.1248/cpb.55.950

DO - 10.1248/cpb.55.950

M3 - Journal article

SN - 0009-2363

VL - 55

SP - 950

EP - 952

JO - Chemical and Pharmaceutical Bulletin

JF - Chemical and Pharmaceutical Bulletin

IS - 6

ER -

Two new xanthones isolated from the stem bark of Garcinia lancilimba

Abstract

Scopus Subject Areas

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UN SDGs

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