Two new triterpene saponins from the anti-inflammatory saponin fraction of Ilex pubescens root

Jing Rong Wang, Hua Zhou, Zhi Hong JIANG*, Liang LIU

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Citations (Scopus)

Abstract

The saponin fraction from the ethanolic extracts of the root of Ilex pubescens Hook. et ARN. (Ilexaceae) was found to exhibit potent anti-inflammatory effects on carrageenan-induced paw edema in rats. Two novel triterpene saponins, pubescenosides C and D (1 and 2, resp.), together with five known saponins were isolated from this saponin fraction. The structures of 1 and 2 were elucidated as (20β)-3-O-[β-D-glucopyranosyl- (1→2)-β-D-xylopyranosyl]ursa- 12,18-dien-28-oic acid 28-O-β-d-glucopyranosyl ester, and (20β)-3-O-[α-L-rhamnopyranosyl- (1→2)-β-D-glucopyranosyl-(1→2)-β- D-xylopyranosyl]ursa-12, 18-dien-28-oic acid 28-O-β-D-glucopyranosyl ester, respectively, on the basis of chemical and spectroscopic data. Five known saponins isolated from the saponin fraction were identified as ilexsaponin B1, B2, B3, A1, and chikusetsusaponin IVa (3-7, resp.).

Original languageEnglish
Pages (from-to)1369-1376
Number of pages8
JournalChemistry and Biodiversity
Volume5
Issue number7
DOIs
Publication statusPublished - 2008

Scopus Subject Areas

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Molecular Medicine
  • Molecular Biology

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