Abstract
The validation of the selective, potent and systemically active non-competitive mGlu1 antagonists YM-298198 and JNJ16259685 in a physiological functional assay will facilitate elucidation of this receptor's role in brain function and as a potential drug target.
| Original language | English |
|---|---|
| Pages (from-to) | 723-724 |
| Number of pages | 2 |
| Journal | British Journal of Pharmacology |
| Volume | 151 |
| Issue number | 6 |
| Early online date | 14 May 2007 |
| DOIs | |
| Publication status | Published - Jul 2007 |
| Externally published | Yes |
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
User-Defined Keywords
- Drug target
- Metabotropic glutamate receptors
- mGlu1
- Purkinje neuron
- Synaptic potential
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