Two new non-competitive mGlu1 receptor antagonists are potent tools to unravel functions of this mGlu receptor subtype

T. Knöpfel

doi:10.1038/sj.bjp.0707289

Two new non-competitive mGlu1 receptor antagonists are potent tools to unravel functions of this mGlu receptor subtype

T. Knöpfel^*

^*Corresponding author for this work

Research output: Contribution to journal › Journal article › peer-review

8 Citations (Scopus)

Abstract

The validation of the selective, potent and systemically active non-competitive mGlu1 antagonists YM-298198 and JNJ16259685 in a physiological functional assay will facilitate elucidation of this receptor's role in brain function and as a potential drug target.

Original language	English
Pages (from-to)	723-724
Number of pages	2
Journal	British Journal of Pharmacology
Volume	151
Issue number	6
Early online date	14 May 2007
DOIs	https://doi.org/10.1038/sj.bjp.0707289
Publication status	Published - Jul 2007
Externally published	Yes

User-Defined Keywords

Drug target
Metabotropic glutamate receptors
mGlu1
Purkinje neuron
Synaptic potential

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/sj.bjp.0707289

Cite this

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title = "Two new non-competitive mGlu1 receptor antagonists are potent tools to unravel functions of this mGlu receptor subtype",

abstract = "The validation of the selective, potent and systemically active non-competitive mGlu1 antagonists YM-298198 and JNJ16259685 in a physiological functional assay will facilitate elucidation of this receptor's role in brain function and as a potential drug target.",

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author = "T. Kn{\"o}pfel",

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KW - Metabotropic glutamate receptors

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KW - Purkinje neuron

KW - Synaptic potential

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Two new non-competitive mGlu1 receptor antagonists are potent tools to unravel functions of this mGlu receptor subtype

Abstract

User-Defined Keywords

UN SDGs

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