Two new Daphniphyllum alkaloids from Daphniphyllum macropodum Miq.

Zhen Yu Li; Hong Gui Xu; Zhongzhen ZHAO; Yue Wei Guo

doi:10.1080/10286020802618837

Two new Daphniphyllum alkaloids from Daphniphyllum macropodum Miq.

Zhen Yu Li, Hong Gui Xu, Zhongzhen ZHAO, Yue Wei Guo^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

8 Citations (Scopus)

Abstract

Two new Daphniphyllum alkaloids, 4,21-deacetyl-deoxyyuzurimine (1) and macropodumine L (2), together with the two known related alkaloids, have been isolated from the bark of Daphniphyllum macropodum Miq. The structures of the new compounds were elucidated on the basis of the detailed analysis of spectroscopic data, chemical method, and by comparison of the spectroscopic data with those of known compounds. Compounds 2 and 4 exhibited weak cytotoxicity against human carcinoma cell lines SMMC-7721 and HO-8910.

Original language	English
Pages (from-to)	153-158
Number of pages	6
Journal	Journal of Asian Natural Products Research
Volume	11
Issue number	2
DOIs	https://doi.org/10.1080/10286020802618837
Publication status	Published - Feb 2009

Scopus Subject Areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

User-Defined Keywords

Alkaloids
Cytotoxicity
Daphniphyllum macropodum Miq

Access to Document

10.1080/10286020802618837

Cite this

@article{a8baeec7465b49dfbaeb315327d0de5f,

title = "Two new Daphniphyllum alkaloids from Daphniphyllum macropodum Miq.",

abstract = "Two new Daphniphyllum alkaloids, 4,21-deacetyl-deoxyyuzurimine (1) and macropodumine L (2), together with the two known related alkaloids, have been isolated from the bark of Daphniphyllum macropodum Miq. The structures of the new compounds were elucidated on the basis of the detailed analysis of spectroscopic data, chemical method, and by comparison of the spectroscopic data with those of known compounds. Compounds 2 and 4 exhibited weak cytotoxicity against human carcinoma cell lines SMMC-7721 and HO-8910.",

keywords = "Alkaloids, Cytotoxicity, Daphniphyllum macropodum Miq",

author = "Li, {Zhen Yu} and Xu, {Hong Gui} and Zhongzhen ZHAO and Guo, {Yue Wei}",

note = "Funding Information: This research work was financially supported by the National Marine {\textquoteleft}863{\textquoteright} projects (Nos 2006A A09Z447, 2006AA09Z412, and 2007AA09Z447), Natural Science Foundation of China (Nos 30730108 and 20721003), STCSM projects (Nos 07XD14036 and 06DZ22028), and CAS Key Project (grant KSCX2-YW-R-18). We are grateful to Prof. Huang Cai-Guo of Second Military Medical University for the cytotoxic activity test.",

year = "2009",

month = feb,

doi = "10.1080/10286020802618837",

language = "English",

volume = "11",

pages = "153--158",

journal = "Journal of Asian Natural Products Research",

issn = "1028-6020",

publisher = "Taylor and Francis",

number = "2",

}

TY - JOUR

T1 - Two new Daphniphyllum alkaloids from Daphniphyllum macropodum Miq.

AU - Li, Zhen Yu

AU - Xu, Hong Gui

AU - ZHAO, Zhongzhen

AU - Guo, Yue Wei

N1 - Funding Information: This research work was financially supported by the National Marine ‘863’ projects (Nos 2006A A09Z447, 2006AA09Z412, and 2007AA09Z447), Natural Science Foundation of China (Nos 30730108 and 20721003), STCSM projects (Nos 07XD14036 and 06DZ22028), and CAS Key Project (grant KSCX2-YW-R-18). We are grateful to Prof. Huang Cai-Guo of Second Military Medical University for the cytotoxic activity test.

PY - 2009/2

Y1 - 2009/2

N2 - Two new Daphniphyllum alkaloids, 4,21-deacetyl-deoxyyuzurimine (1) and macropodumine L (2), together with the two known related alkaloids, have been isolated from the bark of Daphniphyllum macropodum Miq. The structures of the new compounds were elucidated on the basis of the detailed analysis of spectroscopic data, chemical method, and by comparison of the spectroscopic data with those of known compounds. Compounds 2 and 4 exhibited weak cytotoxicity against human carcinoma cell lines SMMC-7721 and HO-8910.

AB - Two new Daphniphyllum alkaloids, 4,21-deacetyl-deoxyyuzurimine (1) and macropodumine L (2), together with the two known related alkaloids, have been isolated from the bark of Daphniphyllum macropodum Miq. The structures of the new compounds were elucidated on the basis of the detailed analysis of spectroscopic data, chemical method, and by comparison of the spectroscopic data with those of known compounds. Compounds 2 and 4 exhibited weak cytotoxicity against human carcinoma cell lines SMMC-7721 and HO-8910.

KW - Alkaloids

KW - Cytotoxicity

KW - Daphniphyllum macropodum Miq

UR - http://www.scopus.com/inward/record.url?scp=60749104185&partnerID=8YFLogxK

U2 - 10.1080/10286020802618837

DO - 10.1080/10286020802618837

M3 - Journal article

C2 - 19219728

AN - SCOPUS:60749104185

SN - 1028-6020

VL - 11

SP - 153

EP - 158

JO - Journal of Asian Natural Products Research

JF - Journal of Asian Natural Products Research

IS - 2

ER -

Two new Daphniphyllum alkaloids from Daphniphyllum macropodum Miq.

Abstract

Scopus Subject Areas

User-Defined Keywords

Access to Document

Other files and links

Fingerprint

Cite this