Two new bioactive diterpenes identified from Isodon interruptus

Qi Ji Li, Chen Liang Zhao, Chuen Fai KU, Yu Zhu, Xunjin ZHU, Jing Jie Zhang, Stephen T. Deyrup, Lu Tai Pan*, Hongjie ZHANG

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

In the course of our ongoing studies to discover bioactive chemical constituents from plants in the genus Isodon, two new diterpenes, kunminolide A (1) and rabdokunmin F (2) were isolated from the leaves of the medicinal plant Isodon interruptus. Kunminolide A (1) is a novel abietane-like diterpene with a novel skeleton, herein designated as 9, 10-seco-neoabietane. Rabdokunmin F (2) is an ent-kaurene diterpene with C-18 oxidized to a carboxylic acid group. The structures were determined by spectroscopic means including analysis of 1D- and 2D-NMR spectral data. Crystals of 1 obtained from methanol were suitable for X-ray analysis, which confirmed the chemical structure. Kunminolide A (1) demonstrated chemopreventive potential by inducing QR1 activity with a CD value of 14.3 µM, and rabdokunmin F (2) was found to have cytotoxic activities with IC50 values in the range of 1.1–3.0 µM.

Original languageEnglish
Article number103512
JournalBioorganic Chemistry
Volume95
DOIs
Publication statusPublished - Jan 2020

Scopus Subject Areas

  • Biochemistry
  • Molecular Biology
  • Drug Discovery
  • Organic Chemistry

User-Defined Keywords

  • Antimicrobial activity
  • Cytotoxicity
  • Isodon interruptus
  • Kunminolide A
  • Plant natural products
  • QR1 activity
  • Rabdokunmin F

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