Two new bioactive diterpenes identified from Isodon interruptus

Qi Ji Li, Chen Liang Zhao, Chuen Fai Ku, Yu Zhu, Xun Jin Zhu, Jing Jie Zhang, Stephen T. Deyrup, Lu Tai Pan*, Hong Jie Zhang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

In the course of our ongoing studies to discover bioactive chemical constituents from plants in the genus Isodon, two new diterpenes, kunminolide A (1) and rabdokunmin F (2) were isolated from the leaves of the medicinal plant Isodon interruptus. Kunminolide A (1) is a novel abietane-like diterpene with a novel skeleton, herein designated as 9, 10-seco-neoabietane. Rabdokunmin F (2) is an ent-kaurene diterpene with C-18 oxidized to a carboxylic acid group. The structures were determined by spectroscopic means including analysis of 1D- and 2D-NMR spectral data. Crystals of 1 obtained from methanol were suitable for X-ray analysis, which confirmed the chemical structure. Kunminolide A (1) demonstrated chemopreventive potential by inducing QR1 activity with a CD value of 14.3 µM, and rabdokunmin F (2) was found to have cytotoxic activities with IC50 values in the range of 1.1–3.0 µM.

Original languageEnglish
Article number103512
JournalBioorganic Chemistry
Volume95
DOIs
Publication statusPublished - Jan 2020

Scopus Subject Areas

  • Biochemistry
  • Molecular Biology
  • Drug Discovery
  • Organic Chemistry

User-Defined Keywords

  • Antimicrobial activity
  • Cytotoxicity
  • Isodon interruptus
  • Kunminolide A
  • Plant natural products
  • QR1 activity
  • Rabdokunmin F

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