Two antifungal components isolated from fructus psoraleae and folium eucalypti globuli by bioassay-guided purification

Kit Man Lau; Lai Hong Fu; Ling Cheng; Chun Wai Wong; Yin Lai Wong; Ching Po Lau; Simon Quan Bin Han; Paul Kay Sheung Chan; Kwok Pui Fung; Clara Bik San Lau; Mamie Hui; Ping Chung Leung

doi:10.1142/S0192415X10008421

Two antifungal components isolated from fructus psoraleae and folium eucalypti globuli by bioassay-guided purification

Kit Man Lau, Lai Hong Fu, Ling Cheng, Chun Wai Wong, Yin Lai Wong, Ching Po Lau, Simon Quan Bin Han, Paul Kay Sheung Chan, Kwok Pui Fung, Clara Bik San Lau, Mamie Hui, Ping Chung Leung^*

^*Corresponding author for this work

Chinese Medicine - Teaching and Research Division

Research output: Contribution to journal › Journal article › peer-review

36 Citations (Scopus)

Abstract

Fructus Psoraleae and Folium Eucalypti Globuli have long been used as Chinese medicines to treat various ailments such as asthma, eczema and dermatomycosis. In previous studies, their antifungal activities were demonstrated. The aim of the present study was to isolate active antidermatophytic compounds from their ethanolic extracts by means of bioassay-guided purification. Guided by the inhibitory activities on Trichophyton mentagrophytes, Trichophyton rubrum and Paecilomyces variotii, bakuchiol was isolated from the n-hexane fraction of Fructus Psoraleae whilst macrocarpal C was isolated from the n-hexane fraction of Folium Eucalypti Globuli. Both pure compounds could effectively inhibit the growth of dermatophytes in vitro. This is the first paper to report the isolation and identification of active antidermatophytic compounds from Fructus Psoraleae and Folium Eucalypti Globuli by the bioassay-guided purification.

Original language	English
Pages (from-to)	1005-1014
Number of pages	10
Journal	The American Journal of Chinese Medicine
Volume	38
Issue number	5
DOIs	https://doi.org/10.1142/S0192415X10008421
Publication status	Published - Sept 2010

Scopus Subject Areas

Complementary and alternative medicine

User-Defined Keywords

Antifungal
Bakuchiol
Dermatophyte
Eucalyptus globules
Macrocarpal C
Psoralea corylifolia

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10.1142/S0192415X10008421

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Lau, K. M., Fu, L. H., Cheng, L., Wong, C. W., Wong, Y. L., Lau, C. P., Han, S. Q. B., Chan, P. K. S., Fung, K. P., Lau, C. B. S., Hui, M., & Leung, P. C. (2010). Two antifungal components isolated from fructus psoraleae and folium eucalypti globuli by bioassay-guided purification. The American Journal of Chinese Medicine, 38(5), 1005-1014. https://doi.org/10.1142/S0192415X10008421

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title = "Two antifungal components isolated from fructus psoraleae and folium eucalypti globuli by bioassay-guided purification",

abstract = "Fructus Psoraleae and Folium Eucalypti Globuli have long been used as Chinese medicines to treat various ailments such as asthma, eczema and dermatomycosis. In previous studies, their antifungal activities were demonstrated. The aim of the present study was to isolate active antidermatophytic compounds from their ethanolic extracts by means of bioassay-guided purification. Guided by the inhibitory activities on Trichophyton mentagrophytes, Trichophyton rubrum and Paecilomyces variotii, bakuchiol was isolated from the n-hexane fraction of Fructus Psoraleae whilst macrocarpal C was isolated from the n-hexane fraction of Folium Eucalypti Globuli. Both pure compounds could effectively inhibit the growth of dermatophytes in vitro. This is the first paper to report the isolation and identification of active antidermatophytic compounds from Fructus Psoraleae and Folium Eucalypti Globuli by the bioassay-guided purification.",

keywords = "Antifungal, Bakuchiol, Dermatophyte, Eucalyptus globules, Macrocarpal C, Psoralea corylifolia",

author = "Lau, {Kit Man} and Fu, {Lai Hong} and Ling Cheng and Wong, {Chun Wai} and Wong, {Yin Lai} and Lau, {Ching Po} and Han, {Simon Quan Bin} and Chan, {Paul Kay Sheung} and Fung, {Kwok Pui} and Lau, {Clara Bik San} and Mamie Hui and Leung, {Ping Chung}",

note = "Funding Information: This work was supported by Research Fund for the Control of Infectious Diseases (RFCID 05050212), Food and Health Bureau, Hong Kong SAR, China. The authors would also like to thank Dr. Cao Hui of the National Engineering Research Centre for Modernization of Traditional Chinese Medicine, Zhuhai, Guangdong, China for his generous help in TCM authentication.",

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AU - Lau, Kit Man

AU - Fu, Lai Hong

AU - Cheng, Ling

AU - Wong, Chun Wai

AU - Wong, Yin Lai

AU - Lau, Ching Po

AU - Han, Simon Quan Bin

AU - Chan, Paul Kay Sheung

AU - Fung, Kwok Pui

AU - Lau, Clara Bik San

AU - Hui, Mamie

AU - Leung, Ping Chung

N1 - Funding Information: This work was supported by Research Fund for the Control of Infectious Diseases (RFCID 05050212), Food and Health Bureau, Hong Kong SAR, China. The authors would also like to thank Dr. Cao Hui of the National Engineering Research Centre for Modernization of Traditional Chinese Medicine, Zhuhai, Guangdong, China for his generous help in TCM authentication.

PY - 2010/9

Y1 - 2010/9

N2 - Fructus Psoraleae and Folium Eucalypti Globuli have long been used as Chinese medicines to treat various ailments such as asthma, eczema and dermatomycosis. In previous studies, their antifungal activities were demonstrated. The aim of the present study was to isolate active antidermatophytic compounds from their ethanolic extracts by means of bioassay-guided purification. Guided by the inhibitory activities on Trichophyton mentagrophytes, Trichophyton rubrum and Paecilomyces variotii, bakuchiol was isolated from the n-hexane fraction of Fructus Psoraleae whilst macrocarpal C was isolated from the n-hexane fraction of Folium Eucalypti Globuli. Both pure compounds could effectively inhibit the growth of dermatophytes in vitro. This is the first paper to report the isolation and identification of active antidermatophytic compounds from Fructus Psoraleae and Folium Eucalypti Globuli by the bioassay-guided purification.

AB - Fructus Psoraleae and Folium Eucalypti Globuli have long been used as Chinese medicines to treat various ailments such as asthma, eczema and dermatomycosis. In previous studies, their antifungal activities were demonstrated. The aim of the present study was to isolate active antidermatophytic compounds from their ethanolic extracts by means of bioassay-guided purification. Guided by the inhibitory activities on Trichophyton mentagrophytes, Trichophyton rubrum and Paecilomyces variotii, bakuchiol was isolated from the n-hexane fraction of Fructus Psoraleae whilst macrocarpal C was isolated from the n-hexane fraction of Folium Eucalypti Globuli. Both pure compounds could effectively inhibit the growth of dermatophytes in vitro. This is the first paper to report the isolation and identification of active antidermatophytic compounds from Fructus Psoraleae and Folium Eucalypti Globuli by the bioassay-guided purification.

KW - Antifungal

KW - Bakuchiol

KW - Dermatophyte

KW - Eucalyptus globules

KW - Macrocarpal C

KW - Psoralea corylifolia

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JF - The American Journal of Chinese Medicine

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ER -

Two antifungal components isolated from fructus psoraleae and folium eucalypti globuli by bioassay-guided purification

Abstract

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