Triptolide targets on MYC towards testis may induce male reproductive toxicity

Guang Zheng, Minghui Yang, Yun Yang, Jihua Wang, Hongtao Guo, Xiaojuan He

Research output: Chapter in book/report/conference proceedingConference contributionpeer-review

3 Citations (Scopus)

Abstract

Extracted from Chinese herbal medicine Tripterygium wilfordii Hook f., triptolide is an active compound with positive therapeutic effects on immune-regulated disease of rheumatoid arthritis. However, the male reproductive toxicity blocks its wider clinical applications. With the mechanisms of male toxicity is still obscure, it is difficult to tackle its toxicity. In this study, triptolide's male reproductive toxicity mechanisms were carried out through integrated bioinformatics analysis which covers target proteins, further regulated testis proteins, biological process enrichment, and protein-protein interactions. As a result, (1) MYC was identified as the target protein; (2) testis proteins of CCNB1, EZH2, PEG10, and THBS1 were found participated in spermatogenesis; and (3) 3 new candidate testis proteins of CHKA, GAS1, and RCC1 were proposed which might be connected to the male reproductive toxicity.

Original languageEnglish
Title of host publicationProceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016
EditorsKevin Burrage, Qian Zhu, Yunlong Liu, Tianhai Tian, Yadong Wang, Xiaohua Tony Hu, Qinghua Jiang, Jiangning Song, Shinichi Morishita, Kevin Burrage, Guohua Wang
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1047-1050
Number of pages4
ISBN (Electronic)9781509016105
DOIs
Publication statusPublished - 17 Jan 2017
Event2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016 - Shenzhen, China
Duration: 15 Dec 201618 Dec 2016

Publication series

NameProceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016

Conference

Conference2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016
Country/TerritoryChina
CityShenzhen
Period15/12/1618/12/16

Scopus Subject Areas

  • Genetics
  • Medicine (miscellaneous)
  • Genetics(clinical)
  • Biochemistry, medical
  • Biochemistry
  • Molecular Medicine
  • Health Informatics

User-Defined Keywords

  • Apoptosis
  • Cell cycle arrest
  • Male reproductive toxicity
  • MYC
  • Testis
  • Triptolide

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