Triptolide regulates immune response network against systemic lupus erythematosus

Guang Zheng; Zhibin Wang; Chengqiang Li; Hongtao Guo; Jihua Wang; Xiaojuan He

doi:10.1109/BIBM.2016.7822729

Triptolide regulates immune response network against systemic lupus erythematosus

Guang Zheng
, Zhibin Wang
, Chengqiang Li
, Hongtao Guo
, Jihua Wang
, Xiaojuan He

Research output: Chapter in book/report/conference proceeding › Conference proceeding › peer-review

1 Citation (Scopus)

Abstract

Traditional Chinese medicine has been using Tripterygium wilfordii Hook f. (TWHF) against systemic lupus erythematosus (SLE) over 200 years. Triptolide is an active compound of TWHF with therapeutic effects for auto-immune disease SLE. However, till now, few associated studies were reported and little is known about the mechanism of triptolide against SLE which blocks the new drug discovery. In this study, focused on the proteins participated in the process of immune respond, an integrated bioinformatics analysis covering targeted proteins, SLE OMIM genes, biological process enrichment, and protein-protein interactions (PPI) was deployed. As a result, the candidate therapeutic network against SLE with negative regulation of immune response was proposed. It contains a PPI network of 7 targeted proteins and 7 SLE OMIM genes further regulated by triptolide. Primary validation of this network indicating that processes of apoptosis and pro-inflammatory processes were involved.

Original language	English
Title of host publication	Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016
Editors	Kevin Burrage, Qian Zhu, Yunlong Liu, Tianhai Tian, Yadong Wang, Xiaohua Tony Hu, Qinghua Jiang, Jiangning Song, Shinichi Morishita, Kevin Burrage, Guohua Wang
Publisher	IEEE
Pages	1409-1414
Number of pages	6
ISBN (Electronic)	9781509016105
DOIs	https://doi.org/10.1109/BIBM.2016.7822729
Publication status	Published - 17 Jan 2017
Event	2016 IEEE International Conference on Bioinformatics and Biomedicine - Shenzhen, China Duration: 15 Dec 2016 → 18 Dec 2016 https://ieeexplore.ieee.org/xpl/conhome/7811899/proceeding (Conference proceeding) https://cci.drexel.edu/ieeebibm/bibm2016/ (Conference website) https://cci.drexel.edu/ieeebibm/bibm2016/BIBM2016Program.pdf (Conference program)

Publication series

Name	Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016

Conference

Conference	2016 IEEE International Conference on Bioinformatics and Biomedicine
Abbreviated title	BIBM 2016
Country/Territory	China
City	Shenzhen
Period	15/12/16 → 18/12/16
Internet address	https://ieeexplore.ieee.org/xpl/conhome/7811899/proceeding (Conference proceeding) https://cci.drexel.edu/ieeebibm/bibm2016/ (Conference website) https://cci.drexel.edu/ieeebibm/bibm2016/BIBM2016Program.pdf (Conference program)

User-Defined Keywords

Apoptosis
Enrichment analysis
Immune response
Systemic lupus erythematosus
Triptolide

Access to Document

10.1109/BIBM.2016.7822729

Cite this

Zheng, G., Wang, Z., Li, C., Guo, H., Wang, J., & He, X. (2017). Triptolide regulates immune response network against systemic lupus erythematosus. In K. Burrage, Q. Zhu, Y. Liu, T. Tian, Y. Wang, X. T. Hu, Q. Jiang, J. Song, S. Morishita, K. Burrage, & G. Wang (Eds.), Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016 (pp. 1409-1414). Article 7822729 (Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016). IEEE. https://doi.org/10.1109/BIBM.2016.7822729

Zheng, Guang ; Wang, Zhibin ; Li, Chengqiang et al. / Triptolide regulates immune response network against systemic lupus erythematosus. Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016. editor / Kevin Burrage ; Qian Zhu ; Yunlong Liu ; Tianhai Tian ; Yadong Wang ; Xiaohua Tony Hu ; Qinghua Jiang ; Jiangning Song ; Shinichi Morishita ; Kevin Burrage ; Guohua Wang. IEEE, 2017. pp. 1409-1414 (Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016).

@inproceedings{a2e058457a3e495287ffe7de8400510a,

title = "Triptolide regulates immune response network against systemic lupus erythematosus",

abstract = "Traditional Chinese medicine has been using Tripterygium wilfordii Hook f. (TWHF) against systemic lupus erythematosus (SLE) over 200 years. Triptolide is an active compound of TWHF with therapeutic effects for auto-immune disease SLE. However, till now, few associated studies were reported and little is known about the mechanism of triptolide against SLE which blocks the new drug discovery. In this study, focused on the proteins participated in the process of immune respond, an integrated bioinformatics analysis covering targeted proteins, SLE OMIM genes, biological process enrichment, and protein-protein interactions (PPI) was deployed. As a result, the candidate therapeutic network against SLE with negative regulation of immune response was proposed. It contains a PPI network of 7 targeted proteins and 7 SLE OMIM genes further regulated by triptolide. Primary validation of this network indicating that processes of apoptosis and pro-inflammatory processes were involved.",

keywords = "Apoptosis, Enrichment analysis, Immune response, Systemic lupus erythematosus, Triptolide",

author = "Guang Zheng and Zhibin Wang and Chengqiang Li and Hongtao Guo and Jihua Wang and Xiaojuan He",

note = "Publisher Copyright: {\textcopyright} 2016 IEEE. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.; 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016 ; Conference date: 15-12-2016 Through 18-12-2016",

year = "2017",

month = jan,

day = "17",

doi = "10.1109/BIBM.2016.7822729",

language = "English",

series = "Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016",

publisher = "IEEE",

pages = "1409--1414",

editor = "Kevin Burrage and Qian Zhu and Yunlong Liu and Tianhai Tian and Yadong Wang and Hu, \{Xiaohua Tony\} and Qinghua Jiang and Jiangning Song and Shinichi Morishita and Kevin Burrage and Guohua Wang",

booktitle = "Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016",

address = "United States",

url = "https://ieeexplore.ieee.org/xpl/conhome/7811899/proceeding, https://cci.drexel.edu/ieeebibm/bibm2016/, https://cci.drexel.edu/ieeebibm/bibm2016/BIBM2016Program.pdf",

}

Zheng, G, Wang, Z, Li, C, Guo, H, Wang, J & He, X 2017, Triptolide regulates immune response network against systemic lupus erythematosus. in K Burrage, Q Zhu, Y Liu, T Tian, Y Wang, XT Hu, Q Jiang, J Song, S Morishita, K Burrage & G Wang (eds), Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016., 7822729, Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016, IEEE, pp. 1409-1414, 2016 IEEE International Conference on Bioinformatics and Biomedicine, Shenzhen, China, 15/12/16. https://doi.org/10.1109/BIBM.2016.7822729

Triptolide regulates immune response network against systemic lupus erythematosus. / Zheng, Guang; Wang, Zhibin; Li, Chengqiang et al.
Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016. ed. / Kevin Burrage; Qian Zhu; Yunlong Liu; Tianhai Tian; Yadong Wang; Xiaohua Tony Hu; Qinghua Jiang; Jiangning Song; Shinichi Morishita; Kevin Burrage; Guohua Wang. IEEE, 2017. p. 1409-1414 7822729 (Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016).

Research output: Chapter in book/report/conference proceeding › Conference proceeding › peer-review

TY - GEN

T1 - Triptolide regulates immune response network against systemic lupus erythematosus

AU - Zheng, Guang

AU - Wang, Zhibin

AU - Li, Chengqiang

AU - Guo, Hongtao

AU - Wang, Jihua

AU - He, Xiaojuan

PY - 2017/1/17

Y1 - 2017/1/17

N2 - Traditional Chinese medicine has been using Tripterygium wilfordii Hook f. (TWHF) against systemic lupus erythematosus (SLE) over 200 years. Triptolide is an active compound of TWHF with therapeutic effects for auto-immune disease SLE. However, till now, few associated studies were reported and little is known about the mechanism of triptolide against SLE which blocks the new drug discovery. In this study, focused on the proteins participated in the process of immune respond, an integrated bioinformatics analysis covering targeted proteins, SLE OMIM genes, biological process enrichment, and protein-protein interactions (PPI) was deployed. As a result, the candidate therapeutic network against SLE with negative regulation of immune response was proposed. It contains a PPI network of 7 targeted proteins and 7 SLE OMIM genes further regulated by triptolide. Primary validation of this network indicating that processes of apoptosis and pro-inflammatory processes were involved.

AB - Traditional Chinese medicine has been using Tripterygium wilfordii Hook f. (TWHF) against systemic lupus erythematosus (SLE) over 200 years. Triptolide is an active compound of TWHF with therapeutic effects for auto-immune disease SLE. However, till now, few associated studies were reported and little is known about the mechanism of triptolide against SLE which blocks the new drug discovery. In this study, focused on the proteins participated in the process of immune respond, an integrated bioinformatics analysis covering targeted proteins, SLE OMIM genes, biological process enrichment, and protein-protein interactions (PPI) was deployed. As a result, the candidate therapeutic network against SLE with negative regulation of immune response was proposed. It contains a PPI network of 7 targeted proteins and 7 SLE OMIM genes further regulated by triptolide. Primary validation of this network indicating that processes of apoptosis and pro-inflammatory processes were involved.

KW - Apoptosis

KW - Enrichment analysis

KW - Immune response

KW - Systemic lupus erythematosus

KW - Triptolide

UR - https://www.scopus.com/pages/publications/85013270096

U2 - 10.1109/BIBM.2016.7822729

DO - 10.1109/BIBM.2016.7822729

M3 - Conference proceeding

AN - SCOPUS:85013270096

T3 - Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016

SP - 1409

EP - 1414

BT - Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016

A2 - Burrage, Kevin

A2 - Zhu, Qian

A2 - Liu, Yunlong

A2 - Tian, Tianhai

A2 - Wang, Yadong

A2 - Hu, Xiaohua Tony

A2 - Jiang, Qinghua

A2 - Song, Jiangning

A2 - Morishita, Shinichi

A2 - Burrage, Kevin

A2 - Wang, Guohua

PB - IEEE

T2 - 2016 IEEE International Conference on Bioinformatics and Biomedicine

Y2 - 15 December 2016 through 18 December 2016

ER -

Zheng G, Wang Z, Li C, Guo H, Wang J, He X. Triptolide regulates immune response network against systemic lupus erythematosus. In Burrage K, Zhu Q, Liu Y, Tian T, Wang Y, Hu XT, Jiang Q, Song J, Morishita S, Burrage K, Wang G, editors, Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016. IEEE. 2017. p. 1409-1414. 7822729. (Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016). doi: 10.1109/BIBM.2016.7822729

Triptolide regulates immune response network against systemic lupus erythematosus

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