Triptolide regulates immune response network against systemic lupus erythematosus

Guang Zheng, Zhibin Wang, Chengqiang Li, Hongtao Guo, Jihua Wang, Xiaojuan He

Research output: Chapter in book/report/conference proceedingConference contributionpeer-review

1 Citation (Scopus)

Abstract

Traditional Chinese medicine has been using Tripterygium wilfordii Hook f. (TWHF) against systemic lupus erythematosus (SLE) over 200 years. Triptolide is an active compound of TWHF with therapeutic effects for auto-immune disease SLE. However, till now, few associated studies were reported and little is known about the mechanism of triptolide against SLE which blocks the new drug discovery. In this study, focused on the proteins participated in the process of immune respond, an integrated bioinformatics analysis covering targeted proteins, SLE OMIM genes, biological process enrichment, and protein-protein interactions (PPI) was deployed. As a result, the candidate therapeutic network against SLE with negative regulation of immune response was proposed. It contains a PPI network of 7 targeted proteins and 7 SLE OMIM genes further regulated by triptolide. Primary validation of this network indicating that processes of apoptosis and pro-inflammatory processes were involved.

Original languageEnglish
Title of host publicationProceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016
EditorsKevin Burrage, Qian Zhu, Yunlong Liu, Tianhai Tian, Yadong Wang, Xiaohua Tony Hu, Qinghua Jiang, Jiangning Song, Shinichi Morishita, Kevin Burrage, Guohua Wang
PublisherInstitute of Electrical and Electronics Engineers Inc.
Pages1409-1414
Number of pages6
ISBN (Electronic)9781509016105
DOIs
Publication statusPublished - 17 Jan 2017
Event2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016 - Shenzhen, China
Duration: 15 Dec 201618 Dec 2016

Publication series

NameProceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016

Conference

Conference2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016
Country/TerritoryChina
CityShenzhen
Period15/12/1618/12/16

Scopus Subject Areas

  • Genetics
  • Medicine (miscellaneous)
  • Genetics(clinical)
  • Biochemistry, medical
  • Biochemistry
  • Molecular Medicine
  • Health Informatics

User-Defined Keywords

  • Apoptosis
  • Enrichment analysis
  • Immune response
  • Systemic lupus erythematosus
  • Triptolide

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