@inproceedings{a2e058457a3e495287ffe7de8400510a,
title = "Triptolide regulates immune response network against systemic lupus erythematosus",
abstract = "Traditional Chinese medicine has been using Tripterygium wilfordii Hook f. (TWHF) against systemic lupus erythematosus (SLE) over 200 years. Triptolide is an active compound of TWHF with therapeutic effects for auto-immune disease SLE. However, till now, few associated studies were reported and little is known about the mechanism of triptolide against SLE which blocks the new drug discovery. In this study, focused on the proteins participated in the process of immune respond, an integrated bioinformatics analysis covering targeted proteins, SLE OMIM genes, biological process enrichment, and protein-protein interactions (PPI) was deployed. As a result, the candidate therapeutic network against SLE with negative regulation of immune response was proposed. It contains a PPI network of 7 targeted proteins and 7 SLE OMIM genes further regulated by triptolide. Primary validation of this network indicating that processes of apoptosis and pro-inflammatory processes were involved.",
keywords = "Apoptosis, Enrichment analysis, Immune response, Systemic lupus erythematosus, Triptolide",
author = "Guang Zheng and Zhibin Wang and Chengqiang Li and Hongtao Guo and Jihua Wang and Xiaojuan He",
note = "Publisher Copyright: {\textcopyright} 2016 IEEE. Copyright: Copyright 2017 Elsevier B.V., All rights reserved.; 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016 ; Conference date: 15-12-2016 Through 18-12-2016",
year = "2017",
month = jan,
day = "17",
doi = "10.1109/BIBM.2016.7822729",
language = "English",
series = "Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016",
publisher = "IEEE",
pages = "1409--1414",
editor = "Kevin Burrage and Qian Zhu and Yunlong Liu and Tianhai Tian and Yadong Wang and Hu, {Xiaohua Tony} and Qinghua Jiang and Jiangning Song and Shinichi Morishita and Kevin Burrage and Guohua Wang",
booktitle = "Proceedings - 2016 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2016",
address = "United States",
}