Triptolide delivery: Nanotechnology-based carrier systems to enhance efficacy and limit toxicity

Qing Ren, Meimei Li, Yun Deng, Aiping LYU*, Jun Lu

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

1 Citation (Scopus)

Abstract

Triptolide (TP) possesses a wide range of biological and pharmacological activities involved in the treatment of various diseases. However, widespread usages of TP raise the urgent issues of the severe toxicity, which hugely limits its further clinical application. The novel functional nanostructured delivery system, which is of great significance in enhancing the efficacy, reducing side effects and improving bioavailability, could improve the enrichment, penetration and controlled release of drugs in the lesion location. Over the past decades, considerable efforts have been dedicated to designing and developing a variety of TP delivery systems with the intention of alleviating the adverse toxicity effects and enhancing the bioavailability. In this review, we briefly summarized and discussed the recent functionalized nano-TP delivery systems for the momentous purpose of guiding further development of novel TP delivery systems and providing perspectives for future clinical applications.

Original languageEnglish
Article number105377
JournalPharmacological Research
Volume165
DOIs
Publication statusPublished - Mar 2021

Scopus Subject Areas

  • Pharmacology

User-Defined Keywords

  • Bioavailability
  • Nanostructured delivery system
  • Side effects
  • Triptolide

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