TY - JOUR
T1 - Triptolide delivery
T2 - Nanotechnology-based carrier systems to enhance efficacy and limit toxicity
AU - Ren, Qing
AU - Li, Meimei
AU - Deng, Yun
AU - Lu, Aiping
AU - Lu, Jun
N1 - Funding Information:
This study was supported by the National Natural Science Foundation of China (Grant No. 81803374 to Jun Lu) and Shenzhen science and technology innovation fund (Grant No. JCYJ20180302174121208 to Jun Lu).
Publisher copyright:
© 2021 Elsevier Ltd. All rights reserved.
PY - 2021/3
Y1 - 2021/3
N2 - Triptolide (TP) possesses a wide range of biological and pharmacological activities involved in the treatment of various diseases. However, widespread usages of TP raise the urgent issues of the severe toxicity, which hugely limits its further clinical application. The novel functional nanostructured delivery system, which is of great significance in enhancing the efficacy, reducing side effects and improving bioavailability, could improve the enrichment, penetration and controlled release of drugs in the lesion location. Over the past decades, considerable efforts have been dedicated to designing and developing a variety of TP delivery systems with the intention of alleviating the adverse toxicity effects and enhancing the bioavailability. In this review, we briefly summarized and discussed the recent functionalized nano-TP delivery systems for the momentous purpose of guiding further development of novel TP delivery systems and providing perspectives for future clinical applications.
AB - Triptolide (TP) possesses a wide range of biological and pharmacological activities involved in the treatment of various diseases. However, widespread usages of TP raise the urgent issues of the severe toxicity, which hugely limits its further clinical application. The novel functional nanostructured delivery system, which is of great significance in enhancing the efficacy, reducing side effects and improving bioavailability, could improve the enrichment, penetration and controlled release of drugs in the lesion location. Over the past decades, considerable efforts have been dedicated to designing and developing a variety of TP delivery systems with the intention of alleviating the adverse toxicity effects and enhancing the bioavailability. In this review, we briefly summarized and discussed the recent functionalized nano-TP delivery systems for the momentous purpose of guiding further development of novel TP delivery systems and providing perspectives for future clinical applications.
KW - Bioavailability
KW - Nanostructured delivery system
KW - Side effects
KW - Triptolide
UR - http://www.scopus.com/inward/record.url?scp=85100408692&partnerID=8YFLogxK
U2 - 10.1016/j.phrs.2020.105377
DO - 10.1016/j.phrs.2020.105377
M3 - Review article
C2 - 33484817
AN - SCOPUS:85100408692
SN - 1043-6618
VL - 165
JO - Pharmacological Research
JF - Pharmacological Research
M1 - 105377
ER -