TY - JOUR
T1 - Triclocarban Exposure Exaggerates Spontaneous Colonic Inflammation in Il-10-/- Mice
AU - Xie, Minhao
AU - Zhang, Hongna
AU - Wang, Weicang
AU - Sherman, Heather L.
AU - Minter, Lisa M.
AU - CAI, Zongwei
AU - Zhang, Guodong
N1 - Funding Information:
New faculty startup from the University of Massachusetts, Amherst (to G.Z.); General Research Fund (12303319) of Hong Kong Research Grants Council (to Z.C.).
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Triclocarban (3,4,4′-trichlorocarbanilide, TCC) is a high-volume chemical used as an antimicrobial ingredient in many consumer and personal care products. In 2016, the Food and Drug Administration removed TCC from over-the-counter hand washing products. However, TCC remains approved to use in many other products and is a ubiquitous contaminant in the environment; furthermore, many common food crops can efficiently accumulate environmental TCC, resulting in potential human exposure through oral ingestion of contaminated food products. Therefore, human exposure to TCC could be a long-lasting and serious problem. A better understanding of its impact on human health could lead to important impact for public health and regulatory policy. Using a spontaneous colonic inflammation model in Il-10-/- mice, here we demonstrate that exposure to TCC, at doses relevant to human exposure, exaggerates spontaneous colonic inflammation in Il-10-/- mice, with reduced colon length, increase fecal concentration of lipocalin 2, enhanced gene expression of Il-6 and Ifn-γin the colon, and exaggerated crypt damage in the colon. Collectively, these results support that TCC could be a potential environmental risk factor of colitis and associated gut diseases.
AB - Triclocarban (3,4,4′-trichlorocarbanilide, TCC) is a high-volume chemical used as an antimicrobial ingredient in many consumer and personal care products. In 2016, the Food and Drug Administration removed TCC from over-the-counter hand washing products. However, TCC remains approved to use in many other products and is a ubiquitous contaminant in the environment; furthermore, many common food crops can efficiently accumulate environmental TCC, resulting in potential human exposure through oral ingestion of contaminated food products. Therefore, human exposure to TCC could be a long-lasting and serious problem. A better understanding of its impact on human health could lead to important impact for public health and regulatory policy. Using a spontaneous colonic inflammation model in Il-10-/- mice, here we demonstrate that exposure to TCC, at doses relevant to human exposure, exaggerates spontaneous colonic inflammation in Il-10-/- mice, with reduced colon length, increase fecal concentration of lipocalin 2, enhanced gene expression of Il-6 and Ifn-γin the colon, and exaggerated crypt damage in the colon. Collectively, these results support that TCC could be a potential environmental risk factor of colitis and associated gut diseases.
KW - colitis
KW - consumer antimicrobials
KW - Il-10 mice
KW - triclocarban (TCC)
UR - http://www.scopus.com/inward/record.url?scp=85081168740&partnerID=8YFLogxK
U2 - 10.1093/toxsci/kfz248
DO - 10.1093/toxsci/kfz248
M3 - Journal article
C2 - 31868902
AN - SCOPUS:85081168740
SN - 1096-6080
VL - 174
SP - 92
EP - 99
JO - Toxicological Sciences
JF - Toxicological Sciences
IS - 1
ER -