TY - JOUR
T1 - Tribulus terrestris and female reproductive system health
T2 - A comprehensive review
AU - Ghanbari, Ali
AU - Akhshi, Nasim
AU - Nedaei, Seyed Ershad
AU - Mollica, Adriano
AU - Aneva, Ina Yosifova
AU - Qi, Yaping
AU - Liao, Pan
AU - Darakhshan, Sara
AU - Farzaei, Mohammad Hosein
AU - Xiao, Jianbo
AU - Echeverría, Javier
N1 - Funding Information:
This work was supported by the Kermanshah University of Medical Sciences (Grant No. 97221 ).
Publisher Copyright:
© 2021
PY - 2021/4
Y1 - 2021/4
N2 - Background: Tribulus terrestris L. (T. terrestris) positive performance on the male sexual system has been confirmed, but little is known about its effects on the female reproductive system. Purpose: This review discussed in detail the beneficial impact of T. terrestris and its secondary metabolites on the female reproductive system. Study design and methods: In this review, the scientific Databases of Science direct, Pubmed, Web of Science, Google, Google Scholar, Researchgate, EMBASE, Scientific Information (SID), and Elsevier were searched profoundly. Studies about the pharmacological activities of T. terrestris on the female reproductive system in each aspect of investigations: human, in vivo, and in vitro studies, in the period from 1998 to 2020 were admitted. Our study was not limited by the language of publications. Results: 23 articles about the effects of T. terrestris on the female reproductive system were found. These studies approved the T. terrestris efficacy on improvements in histological features of the ovary and uterus of polycystic ovary syndrome patients as well as the well-working of normal ovaries, enhancements in the sexual desire of postmenopausal syndrome, improve ovarian and breast cancers. Conclusion: These studies showed that the positive effect of T. terrestris on the female reproductive system was due to the presence of a secondary metabolite called protodioscin; a steroidal saponin compound, as the dominant active component of this plant.
AB - Background: Tribulus terrestris L. (T. terrestris) positive performance on the male sexual system has been confirmed, but little is known about its effects on the female reproductive system. Purpose: This review discussed in detail the beneficial impact of T. terrestris and its secondary metabolites on the female reproductive system. Study design and methods: In this review, the scientific Databases of Science direct, Pubmed, Web of Science, Google, Google Scholar, Researchgate, EMBASE, Scientific Information (SID), and Elsevier were searched profoundly. Studies about the pharmacological activities of T. terrestris on the female reproductive system in each aspect of investigations: human, in vivo, and in vitro studies, in the period from 1998 to 2020 were admitted. Our study was not limited by the language of publications. Results: 23 articles about the effects of T. terrestris on the female reproductive system were found. These studies approved the T. terrestris efficacy on improvements in histological features of the ovary and uterus of polycystic ovary syndrome patients as well as the well-working of normal ovaries, enhancements in the sexual desire of postmenopausal syndrome, improve ovarian and breast cancers. Conclusion: These studies showed that the positive effect of T. terrestris on the female reproductive system was due to the presence of a secondary metabolite called protodioscin; a steroidal saponin compound, as the dominant active component of this plant.
KW - Female reproductive system
KW - Polycystic Ovary Syndrome
KW - Postmenopause
KW - Protodioscin
KW - Tribulus terrestris
UR - http://www.scopus.com/inward/record.url?scp=85101350269&partnerID=8YFLogxK
U2 - 10.1016/j.phymed.2021.153462
DO - 10.1016/j.phymed.2021.153462
M3 - Review article
C2 - 33602600
AN - SCOPUS:85101350269
SN - 0944-7113
VL - 84
JO - Phytomedicine
JF - Phytomedicine
M1 - 153462
ER -
