Trends and perspectives in per-and polyfluorinated alkyl substances (PFASs) determination: Faster and broader

Ke Gao, Yu Chen, Qiao Xue, Jie Fu, Kehan Fu, Jianjie Fu*, Aiqian Zhang, Zongwei CAI, Guibin Jiang

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

27 Citations (Scopus)


Per-and polyfluorinated alkyl substances (PFASs) have been in the spotlight due to their pervasiveness, environmental persistence, bioaccumulation/magnification potential, and possible ecological and health risks. However, the detection of PFASs in the environment represents a longstanding technical challenge. Research on the environmental behavior and risk assessment of PFASs has greatly increased due to advancements in modern analytical methods. Numerous PFASs with varied applications and physicochemical properties are in use, which makes the integrated PFAS analysis challenging. Great advancements in sample pretreatment and instrumental analysis for PFASs have been made since the 2000s, allowing faster and broader PFAS determination. The concern over PFASs in the environment has gradually extended from legacy perfluoroalkyl acids (PFAAs) to novel PFASs. This review outlines the trends and challenges in PFAS determination and proposes perspectives for future PFAS analysis.

Original languageEnglish
Article number116114
JournalTrAC - Trends in Analytical Chemistry
Publication statusPublished - Dec 2020

Scopus Subject Areas

  • Analytical Chemistry
  • Spectroscopy

User-Defined Keywords

  • High resolution mass spectrometry
  • Instrumental analysis technique
  • Non-targeted analysis
  • Per-and polyfluorinated alkyl substances (PFASs)
  • Sample preparation


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