(1) Background: Numerous research studies have investigated and identified the high prevalence of poor mental health status among the Chinese population, for example suffering from a high level of anxiety and depression. Moreover, the Chinese population are shown to have a conservative attitude towards mental health problems and a passive help-seeking behaviour when suffering from psychological distress. Therefore, it is important to assess the levels of self-care among the Chinese population, which is considered as the basis for tackling psychological well-being issues by the World Health Organization (WHO). Self-care was conceptualised and measured by the Mindful Self-Care Scale (MSCS), but without being translated and adapted to the Chinese population. The purpose of this study is to translate the scale into Chinese and to conduct a pilot test to validate the scale among the Chinese population. (2) Methods: Participants (N = 161), with 96 females and 65 males, with an age range from 18 to 62, mage = 26.1 (SD = 6.64), were recruited from Hong Kong (n = 63), Taiwan (n = 44), and mainland China (n = 54) using convenience sampling. (3) Results: The results show a satisfying internal consistency (Cronbach’s α = 0.915) without items that need to be deleted as well as an adequate validity, with Kaiser–Mayer–Olkin (KMO) value of 0.856 and significant correlation between self-care and the two variables: self-compassion and well-being (r = 0.403, r = 0.172, p < 0.001). (4) Conclusions: The results preliminarily indicate that the Chinese version of MSCS is reliable and valid. However, test–retest reliability and confirmatory factor analysis should be performed with a larger sample size for further validation.