Transition metal complexes as imaging or therapeutic agents for neurodegenerative diseases

Edmond Dik Lung MA; Chun Wu; Guodong Li; Tsan Ling Yung; Chung Hang Leung

doi:10.1039/c9tb02669j

Transition metal complexes as imaging or therapeutic agents for neurodegenerative diseases

Edmond Dik Lung MA^*, Chun Wu, Guodong Li, Tsan Ling Yung, Chung Hang Leung^*

^*Corresponding author for this work

Department of Chemistry

Research output: Contribution to journal › Review article › peer-review

34 Citations (Scopus)

Abstract

Neurodegenerative diseases are the result of neurodegeneration, which is the process of losing neuronal functions gradually due to the irreversible damage and death of neurons. Metal complexes have attracted intense interest over recent decades as probes or inhibitors of biomolecules. In this review, we discuss the application of transition metal complexes in the diagnosis and therapy of different neurodegenerative diseases. We first briefly introduce conventional approaches for the diagnosis and treatment of neurodegenerative diseases. Then, the characteristics and mechanisms of transition metal complexes as luminescent probes and drug candidates are discussed. Representative examples of the use of metal complexes in targeted detection and treatment of neurodegenerative diseases are highlighted. Finally, the challenges and future perspectives of this field are presented.

Original language	English
Pages (from-to)	4715-4725
Number of pages	11
Journal	Journal of Materials Chemistry B
Volume	8
Issue number	22
DOIs	https://doi.org/10.1039/c9tb02669j
Publication status	Published - 14 Jun 2020

Scopus Subject Areas

Chemistry(all)
Biomedical Engineering
Materials Science(all)

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title = "Transition metal complexes as imaging or therapeutic agents for neurodegenerative diseases",

abstract = "Neurodegenerative diseases are the result of neurodegeneration, which is the process of losing neuronal functions gradually due to the irreversible damage and death of neurons. Metal complexes have attracted intense interest over recent decades as probes or inhibitors of biomolecules. In this review, we discuss the application of transition metal complexes in the diagnosis and therapy of different neurodegenerative diseases. We first briefly introduce conventional approaches for the diagnosis and treatment of neurodegenerative diseases. Then, the characteristics and mechanisms of transition metal complexes as luminescent probes and drug candidates are discussed. Representative examples of the use of metal complexes in targeted detection and treatment of neurodegenerative diseases are highlighted. Finally, the challenges and future perspectives of this field are presented.",

author = "MA, {Edmond Dik Lung} and Chun Wu and Guodong Li and Yung, {Tsan Ling} and Leung, {Chung Hang}",

note = "Funding Information: This work was supported by Hong Kong Baptist University (FRG2/17-18/003), the Health and Medical Research Fund (HMRF/14150561), the National Natural Science Foundation of China (21575121 and 21775131), the Hong Kong Baptist University Century Club Sponsorship Scheme 2018, the Interdisciplinary Research Matching Scheme (RC-IRMS/16-17/03), Interdisciplinary Research Clusters Matching Scheme (RC-IRCs/ 17-18/03), Collaborative Research Fund (C5026-16G), SKLEBA and HKBU Strategic Development Fund (SKLP_1718_P04), The Science and Technology Development Fund, Macau SAR (File no. 0072/ 2018/A2), and the University of Macau (MYRG2018-00187-ICMS and MYRG2019-00002-ICMS).",

year = "2020",

month = jun,

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doi = "10.1039/c9tb02669j",

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journal = "Journal of Materials Chemistry B",

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T1 - Transition metal complexes as imaging or therapeutic agents for neurodegenerative diseases

AU - MA, Edmond Dik Lung

AU - Wu, Chun

AU - Li, Guodong

AU - Yung, Tsan Ling

AU - Leung, Chung Hang

N1 - Funding Information: This work was supported by Hong Kong Baptist University (FRG2/17-18/003), the Health and Medical Research Fund (HMRF/14150561), the National Natural Science Foundation of China (21575121 and 21775131), the Hong Kong Baptist University Century Club Sponsorship Scheme 2018, the Interdisciplinary Research Matching Scheme (RC-IRMS/16-17/03), Interdisciplinary Research Clusters Matching Scheme (RC-IRCs/ 17-18/03), Collaborative Research Fund (C5026-16G), SKLEBA and HKBU Strategic Development Fund (SKLP_1718_P04), The Science and Technology Development Fund, Macau SAR (File no. 0072/ 2018/A2), and the University of Macau (MYRG2018-00187-ICMS and MYRG2019-00002-ICMS).

PY - 2020/6/14

Y1 - 2020/6/14

N2 - Neurodegenerative diseases are the result of neurodegeneration, which is the process of losing neuronal functions gradually due to the irreversible damage and death of neurons. Metal complexes have attracted intense interest over recent decades as probes or inhibitors of biomolecules. In this review, we discuss the application of transition metal complexes in the diagnosis and therapy of different neurodegenerative diseases. We first briefly introduce conventional approaches for the diagnosis and treatment of neurodegenerative diseases. Then, the characteristics and mechanisms of transition metal complexes as luminescent probes and drug candidates are discussed. Representative examples of the use of metal complexes in targeted detection and treatment of neurodegenerative diseases are highlighted. Finally, the challenges and future perspectives of this field are presented.

AB - Neurodegenerative diseases are the result of neurodegeneration, which is the process of losing neuronal functions gradually due to the irreversible damage and death of neurons. Metal complexes have attracted intense interest over recent decades as probes or inhibitors of biomolecules. In this review, we discuss the application of transition metal complexes in the diagnosis and therapy of different neurodegenerative diseases. We first briefly introduce conventional approaches for the diagnosis and treatment of neurodegenerative diseases. Then, the characteristics and mechanisms of transition metal complexes as luminescent probes and drug candidates are discussed. Representative examples of the use of metal complexes in targeted detection and treatment of neurodegenerative diseases are highlighted. Finally, the challenges and future perspectives of this field are presented.

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JO - Journal of Materials Chemistry B

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Transition metal complexes as imaging or therapeutic agents for neurodegenerative diseases

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