Transformation of ginsenosides from notoginseng by artificial gastric juice can increase cytotoxicity toward cancer cells

Jing Rong Wang, Lee Fong Yau, Rui Zhang, Yun Xia, Jing MA, Hing Man Ho, Ping Hu, Ming Hu, Liang LIU*, Zhi Hong JIANG

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

Multicomponent metabolic profile of notoginseng saponins in artificial gastric juice was qualitatively and quantitatively investigated, showing that ginsenosides were transformed via multiple pathways including deglycosylation, dehydration, hydration, and oxygenation. A total of 83 metabolites was identified by using UPLC-Q-TOF-MS, among which 16 new dammarane glycosides were further characterized by comparing with synthesized authentic compounds. Transformation time-course of notoginseng saponins in artificial gastric juice was quantitatively measured for the first time, showing rapid degradation of primary ginsenosides and concomitant formation of deglycosylation, hydration, and dehydration products. It was further demonstrated that the resultant metabolites exhibited enhanced cytotoxicity toward cancer cells. The extensive metabolism of ginsenosides within a transit time span in stomach, together with the formation of metabolites with diversified chemical structures possessing enhanced biological activities, indicated an important role of transformation in gastric juice in the systematic effects of ginsenosides.

Original languageEnglish
Pages (from-to)2558-2573
Number of pages16
JournalJournal of Agricultural and Food Chemistry
Volume62
Issue number12
DOIs
Publication statusPublished - 26 Mar 2014

Scopus Subject Areas

  • Chemistry(all)
  • Agricultural and Biological Sciences(all)

User-Defined Keywords

  • gastric juice
  • ginsenoside
  • LC-MS
  • notoginseng
  • transformation

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